... design of the study. RZL and HZZ reviewed the IHC
slices. ZQW and YHL participated in the statistical analysis. RHX conceived of
the study, and participated in its design and coordination and helped ... chemo therapy. With this standard,
only 23 patients had positiv e expression, with 7 out of
62 clinical benefit cases (CR+PR+SD) from chemother-
apy and 16 out of 18 PD cas...
... level of ABCC2 mRNA
expression for about 72%, and named as CNE2/
shABCC2-1 and -2, respectively (Fig. 1B).
To further confirm the specificity of siRNA-mediated
silencing of ABCC2, the detection of ... calibration curve was y = 1.59x +
17.917(y stands for peak height of cisplatin and x stands
for concentration of cisplatin). Based on this equation,
the concentration of cisp...
... One of the reasons is our lack of under-
standing in the pathogenesis and natural history of several
tremor disorders.
Current theories suggest that tremor is driven by complex
combinations of ... models of tremor [7]. This is
the case for instance with the model of acute administra-
tion of harmaline in rodents [8], widely used to mimic
essential tremor, or for the animal m...
... a
variety of human and rodent tumors [5,6,10,11] and that
synthetic ligands to this receptor could play an important
role in cancer diagnosis and therapy [12]. We have previ-
ously reported that ... pancreas cancer and weakly expressed in nor-
mal pancreas [13]. In this same study, we carefully charac-
terized the receptor-ligand binding interaction and
reported the Kd and Bmax...
... assay.
HPLC analysis of the synthesis and release of DA by RPE cellsFigure 5
HPLC analysis of the synthesis and release of DA by
RPE cells.(A) HPLC analysis of standard of DA, 3,4-dihy-
droxyphenylacetic ... designed by MM and WL and were per-
formed by MM, XL, and XF. Human RPE cells were sepa-
rated and cultured by QG. DY, LL and SC gave advises on
the work and...
... extraction and CTL
assays.
All the animals were housed and handled in accordance
with the European guidelines no. 86/609/CEE and 116/92
for the protection of laboratory experimental animals and
laboratory ...
HPV-16 E6 and E7 oncogenes for the therapy of cervical carcinoma elicit
humoral and cell-mediated responses in rabbits Journal of Translational Medi-
cine 2010, 8:40...
... molecular and biological fea-
tures of the modified cells and the method of their
proposed administration. This Commentary presents an
example of such a discussion from the current state of the
art ... (engraftment AND 2
nd
generation) is too much
risk. A 0
→ Strategy 4 test presumes much about the
quality of our knowledge of the potential normal tissue
targets and their...
... kground of the host, microflora and target
tissue. As such, T
reg
depletion, or alterations of the foxp3
gene, as seen in Scurfy mice or IPEX patients, results in a
loss of T
reg
cells, and catastrophic ... an
efficient and timely targeting of activated Treg versus
Teff cells during distinct p hases of T1 D progression.
Several studies report the use of several strategies...
... very well be at the heart of both
the mechanism and advantage of heterologous prime-
boost regimens. Therefore, the remainder of this review
will focus on this key feature and its underlying
mechanism, ... properties of non-
replicating vectors and biological response modifiers by
direct intra-nodal administration of plasmid and pepti de
[19,41]. We showed that the sequenc...
... the reduction of symptoms and the
improvement of physical functioning and general wellbe-
ing [1,2]. These outcomes are typically considered to be
patient-reported outcomes (PRO) and have top-tier ... (QALYs) [24]. The EQ-5D consists of
a 5-dimensional descriptive system and a visual analogue
scale allowing assessment of relevant segments of HRQL:
Health and Quality of L...