... rapidly declined.Indeed, in the United States, the last case of poliomyelitisdue to infection with wild type (wt) virus was reported in 1979. Less than a decade later, in 1988, the World HealthOrganization ... poliovaccine was both safe and effective. Then, in 1963, the development of a second vaccine, the Sabin polio vaccine,was announced. With the introduction of effective vac-cines, the incidence of ... both in vitro and in vivo [31]. The 250-kDa polyprotein encoded by the single ORF canbe further subdivided into regions denoted P1, P2, andP3, encoding the structural and nonstructural proteins.Following...