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Báo cáo hóa học: " The E5 protein of the human papillomavirus type 16 down-regulates HLA-I surface expression in calnexin-expressing but not in calnexin-deficient cells" ppt

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Báo cáo hóa học: "TAp73 is one of the genes responsible for the lack of response to chemotherapy depending on B-Raf mutational status" pot

... involved in the lack of responseto oxaliplatin in monotherapy or combined with cetuximab.Background The incidence of colorectal cancer has been increasing in the last few years, while the age of ... [1]. The advances in the treatment of this disease include studies of single-agen ts vs. combination treatment with 5-FU/leucovorin,irinotecan, oxal iplatin, and capecitabine, and the role of targeted ... oxaliplatin in monotherapyor oxaliplatin plus cetuximab. In comparison, in SW-480 and Caco-2 cells treatedwith oxaliplatin in monotherap y or i n combination withcetuximab, increasing mRNA...
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Báo cáo hóa học: " An exploratory investigation of the influence of publication on translational medicine research" pot

... sample of journals the positioning of the journal in the translationalpathway is likely to affect the chance of an article fallingwithin the first gap in translation being published in the journal ... gaps limited the progress of new interventions through the translationalpathway.Within the UK, the Cooksey report resulted in the reor-ganisation of research funding and the creation of severalnew ... health intervention (or a new indication foran existing intervention) from basic science through toearly phase clinical studies with the aim of establishingproof of concept in humans. The efficacy...
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báo cáo hóa học: " A psychometric evaluation of the PedsQL™ Family Impact Module in parents of children with sickle cell disease" pptx

... number of limitations should be considered in evaluat-ing these study results. The parents were involved in the study during a routine clinic visit and so the reportedscores are not in direct ... mild disease. The Institutional Review Board of the Children's Hospital of Wisconsin/Medical College of Wisconsin approved the study and informed consent was obtained from the par-ents.Outcome ... questionnaire. The psychosocialsummary score is comprised of the average of the items in the emotional, social, and school functioning scales. The physical health summary score is comprised of the aver-age...
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báo cáo hóa học: " Development and validation of the Treatment Related Impact Measure of Weight (TRIM-Weight)" pdf

... 8:19http://www.hqlo.com/content/8/1/19Page 3 of 11based approach. Since longitudinal data are not beingused, one must be cautious in the interpretation of the results in relation to minimally important differences.As these findings ... well as taking into consideration the clinicaland theoretical interpretability of the solution. A screeplot of the principle component solution was used asguidance to the number of components ... and thereby efficacy.Finally, b oth side effects and treatment burden seem todrivemanyofthenegative impacts in the otherdomains, resulting in poor treatment compliance, lead-ing to further...
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báo cáo hóa học: " Cross-diagnostic validity of the Nottingham health profile index of distress (NHPD)" doc

... normally distributed. Secondly, the rationale for the suggested loading of 0.3 as a cut-off to define items tobe included in the independent t-test protocol [38] isunclear and other criteria ... with the model, Rasch derived measures have the same meaningthroughout the range of measurement and the relativelocations of any two items (or persons) are independent of the locations of other ... the observed responses in the sample as divided into six class intervals according to their levels of illness-related distress, indicated by red marks on the x-axis.ABHealth and Quality of...
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báo cáo hóa học: " Internal construct validity of the Warwick-Edinburgh Mental Well-being Scale (WEMWBS): a Rasch analysis using data from the Scottish Health Education Population Survey" potx

... wheremissing values are present. However, the precision of the estimate is reduced to an extent depending on the number of missing items. The Rasch model In satisfying the axioms of conjoint measurement ... Alpha [10]. In order to obtain robust estimates of the internal con-struct validity of the scale, the total data set is randomisedinto two further sets of approximately 50% of cases. Finalresults ... well-being expressed by the item. The model can be expressed in the form of a logit model:where ln is the normal log, P is the probability of personn affirming item i; is the person's level of...
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Báo cáo hóa học: " Validity and reliability of the Spanish version of the DN4 (Douleur Neuropathique 4 questions) questionnaire for differential diagnosis of pain syndromes associated to a neuropathic or somatic component" docx

... in patients withmild pain intensity. The influence of pain intensity on the psychometric properties of neuropathic pain screeningtools had not been previously tested with the DN4 or withother ... neuropathic pain (excluding patients with mixed pain and central neuropathic pain) and non-neuropathic pain. A score > 4 points in the sum of the 10 items of the DN4 questionnaire resulted in the ... <0.001 in all cases, and the highest values of the Youden'sindex). This cut-off point showed, in all cases compared,values of 70% or higher (except for PPV in the case of peripheral NP) in indicators...
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báo cáo hóa học: " Development and validation of the insulin treatment appraisal scale (ITAS) in patients with type 2 diabetes" docx

... with the exception of the item pertainingto weight. Here 54% of the insulin-treated agreed thatinsulin causes weight gain, compared to 23% in the insu-lin naïve. The highest mean score for insulin-naïvepatients ... most striking on item6 (fear of needle injections) where only 6% of the insulin-treated agrees to fearing injections compared to 47% of the insulin-naïve participants.Discussion The findings from ... of the insulin-treatedpatients agree to the item that injecting insulin is painful,compared to 43% in the insulin-naïve group. This sug-gests that despite improved injection devices and thinnerTable...
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báo cáo hóa học: " Development and validation of the WEll-being and Satisfaction of CAREgivers of Children with Diabetes Questionnaire (WE-CARE)" potx

... 0.51Preparing insulin for administration -0.17 0.25 0 .16 0.54Having to administer insulin to your child 0.03 -0.17 0.37 0.67Administering insulin prior to meals -0.00 0.33 0.03 0.63Administering insulin ... 0.50Psychosocial Well-being with Acceptance of Insulin Administration 0.44Ease of Insulin Use with Treatment Satisfaction 0.56Ease of Insulin Use with Acceptance of Insulin Administration 0.61Treatment ... usually mothers, with a mean age of 37.1 years (Table 1). The majority of the subjects werewhite. Because only one of the adults taking part in the study was not the parent of the participating child,...
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