Báo cáo hóa học: " Relationship between the loss of neutralizing antibody binding and fusion activity of the F protein of human respiratory syncytial virus" doc
... better understand
the mechanism of action of HRSV neutralizing antibodies
and the impact of resistance to these antibodies upon the
fusion activity of the F protein. A summary of these results
is ... of the fusion activity of the panel of mutations
described here revealed that the fusion activity of the F
protein is tolerant to multiple...
... review of the evidence on the effects and costs
of implantable cardioverter defibrillator therapy in different
patient groups, and modelling of cost-effectiveness and cost-
utility for these groups ... of the models would be:
Where:
α
0
is a fixed intercept,
α
1
,
α
2
and
α
3
are fixed effects coefficients
β
i
~N(0,
σ
β
2
) are random effects allowing for different...
... consump-
Correlation between BHI
V
and slopes of the hemoglobin signalsFigure 7
Correlation between BHI
V
and slopes of the hemoglobin signals. Scatter diagram of the BHI
V
and of the (left
graph) and (right ... modification of such values during time,
omitting the analysis of the stimulus phase may lead to
uncertainties and poor comprehension of the...
... leading to the preferential hydration of the
protein domain is the driving force of protein stabiliza-
tion or folding [3,4]. Furthermore, the effect of
osmolytes on the functional activity of an enzyme ... Moosavi-Movahedi
AA & Ahmad F (2008) Effect of monomeric and
oligomeric sugar osmolytes on DG
D
, the Gibbs energy
of stabilization of the protei...
... >
TFBGua > BuGua found for the k
cat
of production of
NO from oxidation of these guanidines corresponds
well to the order NOHA > TFBNOHG > BuNOHG
found for 1 ⁄ k
off
app
of the corresponding ... K
d
and k
off
. The fol-
lowing experiments were performed as a first approach
to find the variation in k
off
as a function of the iNOS
substrate structure.
Kinetics...
... inflamed, leading to
swelling, pain, stiffness, and the possible loss of func-
tion. Pathologically, synovial proliferation and de-
struction of the articular cartilage and bone occur in
the ... clear rational cut off for activity (or for
normality) of ESR in RA, the usual clinical trial activ-
ity cutpoints for ESR are 28–30 mm/h [19]. For that
reason, a cut off va...
... [1,2,4,6,7,14,27]. The knee-chest position may
provide a better field of view than broadly used left
lateral Sims’ position, as the buttocks fall to each side,
and finger tips of both hands of the investigator ... skin tags and a funnel-shaped
anus were highly significant (table 8).
Table 8: Types and frequencies of CAF in 807 and in pa-
tients with and without B...
... 1742
α
-FlagEGFP +
α
-Flag
Δ
KIND2-Flag
v-KIND-Flag
dendrite
axon
Δ
KIND1-Flag
Δ
KIND1+2-Flag
KIND1-Flag
Δ
RasN-Flag
α
-FlagEGFP +
α
-Flag
KIND2-Flag
Δ
GEF-Flag
A
B
Fig. 1. Domain structure of the ... 702–744 of MAP2, we performed a pull-
down assay of combinations of EGFP-fused KIND1
or KIND2 of v-KIND with GST-fused CD2-1-6-1 or
CD2-1-6-2 of MAP2. We successfully detected a...
... (Table 2).
We further investigated the differences between the
expression of p53, p21/WAF1, and MDM2 in 181 pairs of
HCC on the basis of different clinical parameters, includ-
ing the gender, age, ... defined as ≥5%
of the tumor cells being positive for p53; further, the
majority of studies have not defined the lower limit for
p53-positive tumor cells. Another caus...
... that there is a
positive relationship between the level of CRF and the
mental and physical health components of HRQOL. To
the best of our knowledge, this is the first study to evaluate
the associations ... age-specific CRF levels, with the lowest CRF level as
the referent. We observed significant positive trends across
CRF categories for the prevalence and OR...