... 4Division of Hematology – Department of Oncology and Hematology-University of Modena and Reggio Emilia, Modena, Italy, 5Laboratory of Immunogenetics, Department of Genetics, Biology and Biochemistry ... the surface B cell receptor (BCR) and dependent to specific molecular features of the BCR itself and/ or to the presence of the BCR-associated molecule ZAP-70, or via other non-BCR-dependent ... with the MDM2 protein [32]. Treatment of various tumor cells with inhibitors of the MDM2-TP53interaction results in rising TP53 levels and subsequentinduction of cell cycle arrest and apoptosis...