báo cáo hóa học:" SPECT/CT-plethysmography – non-invasive quantitation of bone and soft tissue blood flow" ppt

báo cáo hóa học:" In vitro generation of cytotoxic and regulatory T cells by fusions of human dendritic cells and hepatocellular carcinoma cells" docx

... coordination, and preparation of this manuscript.SK, MM, AT, EN, and, YN prepared reagents and PBMCs.SH, HK, and YS prepared fusion cells and performed vac-cination of the patient. TO, KF, JG, and HT ... high levels of IFN-γ pro-duction and lysis of the CEA- and/ or WT1-positive targetsrestricted in HLA-A2 and/ or HLA-A24. Interestingly,fusions of immature DCs generated in the presence of HCC cell ... induction of antigen-specificCTL and the generation of Treg by fusions of DCs and HCC cells. The local tumor-related factorsmay favor the generation of Treg through the inhibition of DCs maturation;...

báo cáo hóa học:" Physiologic upper limit of pore size in the blood-tumor barrier of malignant solid tumors" ppt

... the blood half-lives of Gd-G7 and Gd-G8 dendrimers com-pared to those of the Gd-G5 and Gd-G6 dendrimers. The blood half-lives of Gd-G7 and Gd-G8 dendrimers wereshorter than those of the Gd-G5 and ... gliomas and define the upperlimit of pore size within the BTB of brain tumors and peripheral tumors. We determined the differences in thepermeability of the BTB of an ectopic RG-2 glioma and anorthotopic ... microvasculature of the liver and spleen[31]. Therefore, Gd-G5 and Gd-G6 dendrimerswere not effectively cleared from blood circulation and had longer blood half-lives than Gd-G7 and Gd-G8 den-drimers....

Báo cáo hóa học: " Assessing agonistic potential of a candidate therapeutic anti-IL21R antibody" pptx

... potential of Ab-01 was assessed by measuring expression levels of cytokine storm-associated and IL21 pathway genes in blood of cynomolgus monkeys before and after IV administration of Ab-01.Results: ... etal. Journal of Translational Medicine, in press), and report here on the levels of these biomarkers in blood from monkeys collected before and after high dose IVadministration of Ab-01.MethodsProtein ... designed and performed all the in vitro studies, and the gene and proteinexpression assays for both human and cynomolgus studies reported here, co-wrote the manuscript, and with AAH, FIW and MOT...

Báo cáo hóa học: " A working model of stroke recovery from rehabilitation robotics practitioners" pptx

... Plains, NY, USA, 3Department of Neurology, University of Maryland, School of Medicine, Baltimore, MD, USA and 4Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, ... spontaneously and continuesimperfectly, depends on a myriad of biological and social/economic factors: age, gender, physical and mentalhealth, size and location of lesion, family and other sup-port ... idea of motor recovery as a process of motor re-learning and topresent a "working model" (admittedly speculative) of theprocess of neuro-recovery. We will provide neither anoverview of...

báo cáo hóa học:" Anti-angiogenic effect of high doses of ascorbic acid" pptx

... number of intact tubes and closed loops for control wells, wells with low concentra-tions of AA (1 0–5 0 mg/dl), and wells with high concen-trations of AA (10 0–3 00 mg/dl).Effect of high doses of ... high-concentrations of AA (post intravenousadministration of 15 g, 30 g, and 60 g) and time of expo-sure were established. The infusion of 15 g of ascorbic acidin 45 min raised the plasma level of AA to ... exposure of cells to1 0–5 0 mg/dl of AA during 3–5 h period did not changeenergy metabolism of cells or number of cells. The level of metabolic activity was decreased on 20% for concentra-tions of...

báo cáo hóa học:" Enhanced serum concentrations of transforming growth factor-beta1 in simple fatty liver: is it really benign?" pot

... Normal valueswere in males 2 0–3 70 ng/mL and in females 1 0–1 50 ng/mL. The inter-assay coefficients of variation were 4.2%,5.1% and 6.6% at the concentrations of 37, 221 and 340ng/mL, respectively, ... 3.21.4 3.41.5Median Range Median Range Median RangeBMI‡ 26 2 2–3 0 29 2 7–3 2 29 2 7–3 2Fibrosis score 1 1–3 1 1–2 US steatosis Score 2 1–3 1 1–3 CHC, chronic hepatitis C; FL, fatty liver; NASH, non-alcoholic ... increased expression pat-terns of matrix-metalloproteinases -1, -2, -3, and tissue inhibitors of metalloproteinases -1 and -2 genes couldpromotes the degradation of extra-cellular matrix in anearly...

báo cáo hóa học:" Effective transvascular delivery of nanoparticles across the blood-brain tumor barrier into malignant glioma cells" docx

... Institute (NCI), and the Radiology and Imaging Sciences Program (CC). We thank Guofeng Zhang of the Lab-oratory of Bioengineering and Physical Science (NIBIB) and Yide Mi of the Radiology and Imaging ... within blood and glioma tissue over time following intravenous Gd-dendrimer infusions at doses of 0.03 mmol Gd/kg bw and 0.09 mmol Gd/kg bwFigure 2Gd concentration within blood and glioma tissue ... Gd-dendrimers of higher generations. The blood concentration profile of lowly conjugated Gd-G4dendrimers was similar to the profiles of Gd-G1, Gd-G2 and Gd-G3 dendrimers suggesting rapid clearance fromblood...

báo cáo hóa học:" Phase II trial of Modified Vaccinia Ankara (MVA) virus expressing 5T4 and high dose Interleukin-2 (IL-2) in patients with metastatic renal cell carcinoma" pot

... MVA-5T4 and IL-2. (B) Overall survival of stable (solid line) and progressive (dashed line) disease patients. Numbers of patients at risk at 8, 20 and 28 months are shown below the graph.Journal of ... surgical resection; 2 patientshad complete regression of all metastatic disease (lungs and bone) at initial follow-up and underwent nephrec-tomy of primary tumors, 1 patient had two intra-abdom-inal ... reached (Fig. 4A) at a median follow-up of 20months.Median overall survival of the 12 stable patients has notyet been reached ( 8–3 2 months) and was 28 months ( 2– 28 months) for those with progressive...

báo cáo hóa học:" Highly efficient transduction of human plasmacytoid dendritic cells without phenotypic and functional maturation" docx

... (CD123) and the CD4 [18]. Moreover, asa hallmark of pDC, these cells are BDCA2 and BDCA4(type II C lectin)-positive and CD11c- and CD1a-negative.Trypan blue exclusion and cell counting of LV and ... con-centration of 2–5 × 106 of cells per 20 0–5 00 μl of medium. After 3 hours at 37°C, cells were placed in com-plete medium and analysed by flow cytometry betweenday 5 and day 60.Transduction of CD34-pDCSemi-adherent ... of the EF1 or C 5–1 2 promot-ers are very efficient for transduction of pDC.Immunophenotype of transduced pDCFigure 3Immunophenotype of transduced pDC. Comparative phenotypes of transduced and...

báo cáo hóa học:" Generation in vivo of peptide-specific cytotoxic T cells and presence of regulatory T cells during vaccination with hTERT (class I and II) peptide-pulsed DCs" pot

... DCTs and DCTIs have anoptimal antigen uptake capacity and upregulation of CD86, CD40 and class I, but low levels of CD83, as isexpected of non-terminally mature DCs. The phenotypicprofile of ... ME: conception and logistics of the study. MMA, CV, SS, RAR, SC AJM: vac-cination of patients, acquisition of samples and genera-tion of data. MMA, AJM, NRH, JB, FF: preparation of thevaccine. ... activity of immature and mature DCs [43].The second aim of our study was to evaluate the ability of DC preparations (DCT) pulsed with class I (p540 orp865) and II (p766 and p672) epitopes of hTERT,...

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