... polymeriza-tion by increasing actin nucleation and stabilizing actinfilaments and swinholide A, a drug that sequestersG-actin as dimers [28]. As shown in Fig. 6A, cells treatedwith jasplakinolide assumed ... polymerization o f a ctinmicrofilaments resulting in d ecreased G- to F-actin ratio a ndappeared to be achieved at the t ranscriptional level. The p38signaling pathway was RhoA-independent and led to CTGF/CCN2 ... pharmacomechanicalcoupling to G-proteins and myosin phosphatase. Acta Physiol.Scand. 164, 437–448.24. Uehata, M., Ishizaki, T., Satoh, H., Ono, T., Kawahara, T.,Morishita, T. , Tamakawa, H., Yamagami, K., Inui,...