... data suggest that the 143–156 amino acids of the lipid-binding domain of CAV1 play a key role. On the contrary, the 81–101 amino acids scaffold-domain of CAV1 is irrelevant to CAV1-mediated internalization ... RES induces apoptosisthrough a caspase-dependent pathway. Therefore, the activity of caspase 3, a major component of the caspasepathways, was analyzed. In addition, the role ERKs andp38 kinase ... celldeath in CAVM1 cells. An intriguing mechanism, in thisregard, is the presence of scaffolding domain in caveolin-1 that binds to and inhibits the activity of several signalingproteins in vitro and...