báo cáo hóa học: " Interleukin-1alpha expression precedes IL-1beta after ischemic brain injury and is localised to areas of focal neuronal loss and penumbral tissues" pdf
báo cáo hóa học: " Interleukin-1alpha expression precedes IL-1beta after ischemic brain injury and is localised to areas of focal neuronal loss and penumbral tissues" pdf
... regulation of its release and sterile inflammatory responses [11]. Interleukin-1α expression precedes IL-1β after ischemic brain injury and is localised to areas of focal neuronal loss and penumbral ... primary injury to brain cells is caused by the lack of blood supply and so can be considered sterile. Sterile inflammation is known as a major contributor to disease and injury [14], and IL-1α ... sub-cellular distribution of IL-1α in injured areas is not uniform suggesting that it is regulated. Conclusions The early expression of IL-1α in areas of focal neuronal injury suggests that it is the...
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báo cáo hóa học: " Toll-like receptors in cerebral ischemic inflammatory injury" pdf
... anti-inflammatory mediators areenhanced [13].The role of TLR4 in ischemic brain tolerancePre-exposur e of the brain to a shor t ischemic even t canresult in subsequent resistan ce to severe ischemic injury [13], ... of 11The role of TLR9 in ischemic brain toleranceRecently TLR9 was shown to induce tolerance to brain ischemia [50]. Systemic administration of the immunos-timulus CpG-ODN1826 in advance of ... mechanism of ischemic tolerance will open investigativeavenues into the treatment of cerebral ischemia. In this review, we discuss the critical role of TLRs in mediating cerebral ischemic injury. ...
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báo cáo hóa học:" Gene expression profiling for molecular distinction and characterization of laser captured primary lung cancers" ppt
... group of diseasesin terms of their biology and the clinical course. The diag-nosis and classification of lung cancers are primarilybased on the histological morphology and immunohisto-logical ... fibroticfocus is regarded as an indicator of tumor angiogenesis and independent predictor of early metastasis [35].SCLCs show an up-regulation of 3 proto-oncogenes,which have not been described in this ... theresult of microarray analysis using RT-PCR, showing a 9.3-fold overexpression of the neuronal cell adhesion mole-cule in SCLC in comparison to lung tissue.The imbalance of activated oncogenes and...
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báo cáo hóa học:" Aberrant expression and potency as a cancer immunotherapy target of alpha-methylacyl-coenzyme A racemase in prostate cancer" pptx
... setting to supportthe histological diagnosis of prostate cancer. Because ithas characteristics of cancer-specific expression and fre-quent expression in various cancers, AMACR is an attrac-tive ... target of inhibitor of apoptosis protein family, Livin/ML-IAP in lung cancer. ClinCancer Res 2005, 11:1000-1009.16. Sato T, Sato N, Takahashi S, Koshiba H, Kikuchi K: Specific cytotox-icity of ... (LNCaP,DU145 and PC-3) and in surgically resected prostate can-cer tissues (Figure 1B and 1C). Low levels of expression were detected in non-cancerous prostate tissues (Figure1C).Immunohistochemical...
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Báo cáo hóa học: " High expression of transcriptional coactivator p300 correlates with aggressive features and poor prognosis of hepatocellular carcinoma" doc
... of the histone acetyltransferase family of transcriptionalcoactivator, is found to play a variety of roles in thetranscription process and catalyzes histone acetylationthrough its histone acetyltransferase ... correlateswith nuclear alterations of tumor cells and contributes to the growth of prostate carcinoma and is a predictor of aggressive features of this cancer [14,15].Up to date, the clinicopathologic/p ... among gene targets, it is not verydifficult for us to understand that the function of p300 and its underling mechanism(s) to impact cancer pro-gression may lead to this discrepancy. In addition,although...
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báo cáo hóa học: " Temporal expression and cellular origin of CC chemokine receptors CCR1, CCR2 and CCR5 in the central nervous system: insight into mechanisms of MOG-induced EAE" pptx
... adecrease in the expression of chemokines and adhesionmolecules. Another possibility is the exhaustion of infil-trating leukocytes due to apoptosis. Many studies havedemonstrated apoptosis of infiltrating ... induction of EAE and preparation of tissues(SE, DS, MN), in situ hybridization and immunohisto-chemistry (DS, SE, MN, AE-D), analysis of data (DS, SE,HL, A-LB, AE-D), writing/reviewing of manuscript ... purposes)macrophages and resident microglia to sites of CNS inflammation. Detailed knowledge of expression patterns is crucialfor the understanding of therapeutic modulation and the validation of CCR1, CCR2 and...
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báo cáo hóa học:" Differential expression of type X collagen in a mechanically active 3-D chondrocyte culture system: a quantitative study" docx
... (MMPs) and tissue inhibitors of matrix metalloproteinases(TIMPs), and an increases of the expression of proinflam-matory cytokines IL-1β and TNF-α [14-16]. Thus, differen-tial gene expression ... implications for our understanding of mechanosensitivity of cartilage and mechanicalregulation of chondrocyte gene expression. Published: 06 December 2006Journal of Orthopaedic Surgery and Research 2006, ... maycontribute to osteoarthritic degeneration of some areas of cartilage while other areas remain viable. This mayaccount for heterogeneity of osteoarthritic lesion distribu-tion within a single piece of...
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Báo cáo hóa học: " Differential expression of papillomavirus L1 proteins encoded by authentic and codon modified L1 genes in methylcellulose-treated mouse keratinocytes" pptx
... resulted the KCs to change expression patterns of the other KC differentia-tion markers by reducing expression of basal keratins K14 and increasing expression of keratins K1 and K10 (datanot ... KCsEffects of post-transfection treatment of methylcellulose on expression of PV L1 genes in mouse primary KCsFigure 2Effects of post-transfection treatment of methylcellulose on expression of PV ... purposes)Effects of pre-transfection treatment of methylcellulose on expression of the PV L1 genes in mouse primary KCsFigure 3Effects of pre-transfection treatment of methylcellulose on expression of the...
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Báo cáo hóa học: " Transient expression of homologous hairpin RNA interferes with PVY transmission by aphids" docx
... providesa potential tool to further dissect the molecular mecha-nisms of aphid transmission. Expression of hairpin RNAsdriven by tissue-specific regulatory sequences could beemployed to abort virus ... between the sense and the antisense orienta-tions of the PVY CP sequence. We took advantage of thepositive selection conferred by this prokaryotic resistancegene to reduce the risk of intramolecular ... aphids. BYDV is a persistently transmitted, circulative virus and thus rep-resents a different transmission mechanism, with distinc-tive impact on plant virus epidemiology, to that of PVY[10]....
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