...
Background
Neuromyelitis optica (NMO), a severe inflammatory demyelinating disorder, has
gained increasing interest since the discovery of serum NMO-IgG autoantibodies
targeting the aquaporin-4 (AQP4) ... distribution, and reproduction in any medium, provided the original work is properly cited.
Figure 3
- 1 -
Complement activating antibodies to myelin
oligodendrocyte...
... score. As outlined above,
time of sunlight tolerance and pain intensity are the two
main and interdependent factors in PP -related phototox-
icity. Due to the subjective nature of phototoxicity, only
PP-affected ... fractions, zinc-protoporphyrin and
(metal-)free protoporphyrin. Patients with XLDPT show
a higher proportion of zinc-protoporphyrin than those
with EPP. As zinc-protopo...
... Anthroposophic Medicine (VAOAS), which has the
following prerequisites: Completed specialist training in a
CON discipline, 360 hours of training in AM (as an assist-
ant anthroposophic doctor in a clinic, ... often to deal with emotional
problems than did CON physicians.
Patients increasingly demand medical advice as well as
medical information in a manner and in language that
t...
... Sheng JG, Ito K, Skinner RD, Mrak RE, Rovnaghi CR, Van Eldik LJ, Griffin WS:
In vivo and in vitro evidence supporting a role for the inflammatory
cytokine interleukin-1 as a driving force in Alzheimer ... inflam-
matory cytokine, TNFa, to LPS in vivo to confirm the
activity of this compound and to compare this response
to that of S100B protein. In contrast to results f...
... 37°C), deparaffinized in xylene, rehy-
drated in graded alcohols and rinsed with tap water.
Sections were examined for histopathology following
routine staining with hematoxylin and eosin (H&E;
Sigma-Aldrich,St.Louis,MO).ALDH1,CD44,CD117
and ... counterstained with hematoxylin
(Fischer Scientific) and rinsed in running water (15 min-
utes). Double label immunostaining was ca...
... numerous regulatory proteins including CD59, clus-
terin, vitronectin, C1-inhibitor, C4-binding protein,
decay -activating factor, and Factor H, which inhibit differ-
ent steps in the complement cascade. ... Amyloid
plaques in a transgenic mouse model of Alzheimer's disease
contain complement components and pro-inflammatory
cytokines. In Program No. 491.1. 2000 Abstract Vi...
... Develop specific guidelines for detection of T cell fre-
quencies: IFN-γ ELISPOT [40] and for "other cytokine"
ELISPOTs, intracellular cytokine staining, cytotoxicity
assays, proliferation, ... bioinformat-
ics and clinical strategies to increase the yield of informa-
tion relevant to the mechanism of immune-mediated,
tissue-specific rejection to develop clinically useful...
... underway to support large scale clinical
molecular profilin g efforts and such efforts are beginning
to provide valuable insights with regard to correlates of
efficacy in various clinical settings ... laboratory s tandar ds
in the laboratory of the clinical investigator directing the
trial and (v) They have been budget constrained.
It is perhaps fair to state this approach for...
... against estab-
lished orthotopic and metastatic renal cell carcinoma
without nephrectomy and ascertain if treatment could be
optimized using cytokine support.
Materials and methods
Cell lines and ... of immunity and including
cytokine support for T cells can induce effective anti-tumor responses against orthotopic and metastatic tumors.
Introduction
Immunotherapies involving comb...
... deliv-
ery. In light of the findings of the pilot study, existing lit-
erature on the subject was reviewed and it was decided to
adapt the index to the Indian setting, possibly at the
expense of limiting ... comparability to other settings. In
an attempt to keep the index as simple as possible we
decided to follow the scoring and spending point specifi-
cations for patient g...