... deposition of APP is widespread in the brain,including the cortex and hippocampus. Phosphorylatedtau immunoreactivity is present in neurons and glia in thecortex and hippocampus, and intracellular ... numerous regulatory proteins including CD59, clus-terin, vitronectin, C1-inhibitor, C4-binding protein,decay-activating factor, and Factor H, which inhibit differ-ent steps in the complement cascade. ... activationTAPP and 3xTg-AD miceMutations in the gene encoding for human tau proteinhave been linked to the development of frontotemporaldementia with parkinsonism [115]. By combining thismutation with...