báo cáo hóa học: " Inhibition of microglial inflammatory responses by norepinephrine: effects on nitric oxide and interleukin-1β production" pdf
Báo cáo khoa học: Inhibition of Drosophila melanogaster acetylcholinesterase by high concentrations of substrate potx
... 0.05c–aAcceleration of deacetylation by substrate and substrate ana-logue.bAcceleration of decarbamoylation by substrate analogue.Acceleration of deacetylation and decarbamoylation by substrateanalogue ... enzyme concentration at timet,[E]0theinitialconcentrationoffreeenzymeand[Ec]0the initial concentration of mono-methylcarbamoylatedenzyme.ResultsLocation of residues involved in substrate inhibition To ... proposed. It was postulated by Krupka and Laidler that inhibition of AChE by substrate resulted fromthe inhibition of deacetylation [19]. This would arise fromthe combination of acetylcholine with...
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Báo cáo khoa học: Inhibition of a-synuclein fibrillization by dopamine analogs via reaction with the amino groups of a-synuclein Implication for dopaminergic neurodegeneration pot
... HSQC spectra of the reactions of a-Syn with quinone and DA. (A) Overlay of the1H-15N HSQC spectra of a-Syn (black) and the reaction product of a-Syn and Q (red). (B) Overlay of the1H-15N ... and then the reaction mixtures were analyzed by means of SEC. (B) SDS ⁄ PAGE graph of the fractions from SEC separation of the reaction products of a-Syn with Q (up) or DA (down). The fractionscollected ... assump-tion that flavonoid baicalein inhibits a -Syn fibrilliza-tion by reaction of baicalein quinone with a lysineside-chain of a-Syn to form a Schiff base, and theadditional mass of the product...
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Báo cáo Y học: Inhibition of SERCA Ca2+ pumps by 2-aminoethoxydiphenyl borate (2-APB) 2-APB reduces both Ca2+ binding and phosphoryl transfer from ATP, by interfering with the pathway leading to the Ca2+-binding sites ppt
... 8. Effects of 2-APB on ATP-dependent phosphorylation and nucleotide binding to the Ca2+ATPase. (A) shows the effects of phosphorylation of the SR Ca2+ATPase at varying concentrations of [c-32P]ATP, ... Mechanism of inhibition of the (Ca2+-Mg2+)-ATPase by nonylphenol. Biochemistry 29, 3091–3101.16. Zhong, L. & Inesi, G. (1998) Role of the S3 stalk segment in thethapsigargin concentration ... 3542–3546.Ó FEBS 2002 2-APB inhibition of SERCA (Eur. J. Biochem. 269) 3687RESULTS Inhibition of Ca2+-ATPase activity and Ca2+uptakeFigure 1 shows the effects of 2-APB on Ca2+-dependentATPase...
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báo cáo hóa học:" Activation of human B cells by the agonist CD40 antibody CP-870,893 and augmentation with simultaneous toll-like receptor 9 stimulation" doc
... rapid depletion of circulating CD19+ Bcells and a suggestion of global B cell activation as evi-denced by significant upregulation of CD86 expression on B cells after infusion [14] (JR and RHV, ... major component of T cellhelp. Ligation of CD40 on DC, for example, inducesincreased surface expression of costimulatory and MHCmolecules, production of proinflammatory cytokines, and enhanced ... dual incubationwith CP-870,893 and CpG ODN 2006 compared to CpGODN 2006 alone induced higher expression of activationmarkers only for total B cells and CD27+ memory B cells and only for some,...
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Báo cáo hóa học: " Detection of epithelial apoptosis in pelvic ileal pouches for ulcerative colitis and familial adenomatous polyposis" pot
... comparison of locallevels of Bcl-2 in pouches from UC, FAP patients and controls revealed that they were similar among thegroups (p > 0.05).The expression of FADD and Caspase-8 was similaramong ... number of experiments. Theresults of blots are presented as direct comparisons of bands in autoradiographs and quantified by densito-metry using the Gel-Pro Analyzer 3.1 software (Exon-Intron ... determination of Bax, Bcl-2, FADD - Caspase-8, APAF-1 - Caspase-9 proteinexpressions in non-inflamed pouches in the Control, FAP and UC groups. For illustration purpose each line band represents one...
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Báo cáo hóa học: " Comparison of three rapamycin dosing schedules in A/J Tsc2+/- mice and improved survival with angiogenesis inhibitor or asparaginase treatment in mice with subcutaneous tuberous sclerosis related tumors" docx
... lesions of Woodrum et al. Journal of Translational Medicine 2010, 8:14http://www.translational-medicine.com/content/8/1/14Page 17 of 18Table 2 Distribution of Kidney Lesion Subtype for A/J and ... injection. Vincristine treated groupsreceived 200 μlofa0.075mg/mLsolutionofvincris-tine once per week for four weeks by IP injection.Sunitinib treated groups received 200 μlofa12mg/mL solution of ... Identification of functionalelements in the bidirectional promoter of the mouse Nthl1 and Tsc2genes. Biochem Biophys Res Commun 2000, 273(3):1063-8.30. Kenerson H, Dundon TA, Yeung RS: Effects of rapamycin...
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Báo cáo hóa học: " Incidence of the V600K mutation among melanoma patients with BRAF mutations, and potential therapeutic response to the specific BRAF inhibitor PLX4032" potx
... between the V600E and V600K mutations. Ourpreclinical data demonstrating s imilar kinase activity of the V600K and V600E mutations, together with clearevidence of clinical activity of PLX4032 in ... study of PLX4032: Proof of concept for V600E BRAF mutation as a therapeutic target in humancancer. J Clin Oncol (Meeting Abstracts) 2009, 27:9000.2. Uribe P, Wistuba I, González S: BRAF mutation: ... al.: Incidence of the V600K mutationamong melanoma patients with BRAF mutations, and potentialtherapeutic response to the specific BRAF inhibitor PLX4032. Journal of Translational Medicine 2010...
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báo cáo hóa học: "Quality of life in Brazilian obese adolescents: effects of a long-term multidisciplinary lifestyle therapy" pdf
... affect.Cognition and response to behavioral weight control. J Con-sult Clin Psychol. 1988, 56(3):433-439.23. Gorenstein C, Andrade L: Validation of a Portuguese version of the beck depression inventory and ... depression and anxiety after short and long-term multidisciplinary life-style treatment and, consequently, the improvementobserved in scores of mean dimensions of QOL can beexplained by numerous ... social, and economic consequences that can negativelyaffect quality of life (QOL). Thus the aim of this study was to verify the effects of a long-termmultidisciplinary lifestyle intervention on...
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Báo cáo hóa học: " Quality of Life as reported by school children and their parents: a cross-sectional survey" docx
... correlations betweenmother and daughter, mother and son, father and daugh-ter and father and son reports on the ILC and KINDL weresignificant, but small and similar (range r = 0.25 to 0.31, and ... exploredpossible cluster effects. The results of an analysis of unconditional random effects showed that only 3.6% of the total variance of the ILC LQ0-28 scores and 6.5% of the total KINDL Total ... anal-ysis, interpretation of data and the revising of the manu-script. LW made contribution to the study design,statistical analysis, interpretation of data and the revision of the manuscript....
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Báo cáo khoa học: Induction of raft-like domains by a myristoylated NAP-22 peptide and its Tyr mutant potx
... that the ability of peptides to form domains of PtdIns(4,5)P2 is a conse-quence of the combined interactions of the cationiccluster of amino acid residues and the insertion of hydrophobic amino ... seques-tration to the membrane by removing the anionic por-tion of the protein that would repel anionic lipids. ThepI of rat NAP-22 is only 4.5. Another indication of the importance of the amino ... is charac-teristic of this transition and is caused by the slow rate of interconversion of two forms of anhydrous choles-terol crystals [15]. The polymorphic transition of anhy-drous cholesterol...
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