báo cáo hóa học: " Managing variability in the summary and comparison of gait data" pot
Báo cáo hóa học: " Movement variability in stroke patients and controls performing two upper limb functional tasks: a new assessment methodology" docx
... represent-ative of the variability in the timing of the accelerationsignal, and 2) RMS error, representative of the variability in the signal's magnitude. The warping cost for the glass task ... focusing on the characteristics of the move-ment itself rather than the outcome of the movement (e.g.end point accuracy in a pointing task), is of most benefit in promoting the recovery of normal ... cost. The dynamicprogramming approach enforces the constraint that the warping does not change the temporal order of the datapoints in trial 2. The variability in signal magnitude is then reflected...
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Báo cáo khoa học: Intermodule cooperativity in the structure and dynamics of consecutive complement control modules in human C1r Structural biology docx
... ‘HVL‘ loop, and the presence of a tyrosine in strand C of CCP4 in place of an asparagine in C1r CCP2 (N379), and based on the results of the present perturbation study, we suggestthat the inter-CCP ... in CCP1CCP2, which is exactly the reverse of the situationobserved for the CCP1single and CCP2singlemodules and probably reflects the complex interdependence of the modules in terms of internal ... timescale in both of the free modules.Thus, these loops are strong candidates for binding sites of other complement and ⁄ or regulatory proteins. The large insertion between E and F strands in C1r...
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Báo cáo hóa học: " Oxidative stress in NSC-741909-induced apoptosis of cancer cells" potx
... stress is involved in the cytotoxicity of oncrasin compounds, we examined the production of ROS and its effects on JNK activation and cell death after treatment of oncrasin-sensitive and -resis-tant ... ROS-mediatedapoptosis by increasing the intracellular concentration of ROS through increased oxygen consumption and inhibi-tion of the expression of ROS scavengers downstream of FoxO, particularly ... sensi-tive and involved in apoptosis signaling [12,43,44]. Thereare two mechanisms of JNK activation: the earlier and transient activation occurs through the pro-inflammatorycytokine signaling cascade,...
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Báo cáo hóa học: " Transcriptional responses in the adaptation to ischaemia-reperfusion injury: a study of the effect of ischaemic preconditioning in total knee arthroplasty patients" docx
... antecubital fossa of the upper limb at the initia-tion of surgery and at 1 hour of ischaemia to coincidewith the muscle sampling. Blood was then obtained 30min, 1 hour and 24 hours following tourniquet ... TM and PMW carriedout the experimental work including the extraction of RNA, validation of microarray data by real-time PCR and the analysis of serum samples. The microarray experiment and the ... signallingmolecules such as adenosine [3], bradykinin [9] and reac-tive oxygen species (ROS) [10]. The release of these mole-cules then activates protective signalling pathwaysinvolving kinases...
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Báo cáo hóa học: " Oromotor variability in children with mild spastic cerebral palsy: a kinematic study of speech motor control" docx
... and analysis. CYW carried out the datacollection and interpretation. All authors read and approved the finalmanuscript.Competing interests The authors declare that they have no competing interests.Received: ... part of the high-demanding articul atorytraining program. As we are uncertain whether the brain damage in children with CP can respond to suchtreatment, further studies are needed to investigate ... trial.Furthermore, the coefficient of variation (CV) forkinematic data (utterance durati on, peak opening displa-cement, and peak opening velocity) obtained by dividing the standard deviation of kinematic...
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Tài liệu Báo cáo khoa học: Proton transfer in the oxidative half-reaction of pentaerythritol tetranitrate reductase Structure of the reduced enzyme-progesterone complex and the roles of residues Tyr186, His181 and His184 pdf
... productive binding of steroid substrates: in the first, a (small) sub population of enzyme bindsdirectly the steroid in the reactive conformation, with the remainder of the enzyme binding the unreactiveconformation. ... His181 and His184 are important in the binding of coenzyme, steroids, nitro-aromatic ligands and the substrate 2-cyclohexen-1-one. The H181A and H184A enzymes retain activity in reductive and oxidative ... resolved and are boundbetween the progesterone and the protein (Fig. 7A). In comparison to the oxidized structures, the FMNisoalloxazine ring is less planar, with both the N5atom and the C8-C7...
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Báo cáo khoa học: Structural features in the C-terminal region of the Sinorhizobium meliloti RmInt1 group II intron-encoded protein contribute to its maturase and intron ppt
... suggestedthat the N-terminus of the RT domain is required forprotein interactions with the high-affinity binding site in subdomain DIVa of the intron, whereas otherregions of the RT and domain X interact ... for the insertion of the intron into DNA targets in the orientation that would make it possible to use the nascent leading strandas a primer. These findings suggest that these group II intron intron-encoded ... nonfunctionalextension. In the present study, we investigated the C-terminalregion of the RmInt1 IEP up to the maturase domain and the C-tail. We found that the C-tail and upstreamamino acid residues, located in...
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Báo cáo khoa học: Sulfated polysaccharides inhibit the catabolism and loss of both large and small proteoglycans in explant cultures of tendon doc
... appeared in the mediumon each day of culture and that remaining in the matrix at the end of the culture period [41]. From these data, the per-centage of 35S-labeled proteoglycans remaining in the ... to determine the amounts of glycosaminoglycans remaining in the matrix.Measurement of turnover of 35S-labeledproteoglycans in tendon maintained in culture in medium containing varying concentrations ... coreproteins remaining in the matrixTo determine the effects of CaPPS and heparin, at con-centrations of 1000 lgÆmL)1, on the proteolytic pro-cessing of 35S-labeled proteoglycans remaining in the tendon...
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Báo cáo khoa học: Identification in the yeast Pichia stipitis of the first L-rhamnose-1-dehydrogenase gene docx
... eitherat the N-terminus or at the C-terminus. To introduce the histidine-tag at the N-terminus, we introduced a codingsequence for MHHHHHHGG before the original startcodon. To introduce the ... determinedusing MALDI-TOF MS. This enabled the identification of the correspond-ing gene, RHA1. It codes for a protein with 258 amino acids belonging to the protein family of short-chain alcohol ... trypsination, the peptide masses of the 30 kDaprotein were determined by MALDI-TOF MS. As the genome sequence of P. stipitis is known [12], thesemasses allowed the identification of the protein on the basis...
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Báo cáo hóa học: "Epigenetic change in E-Cardherin and COX-2 to predict chronic periodontitis" pptx
... usedto grind the tissue to a pulp. 200 μl of GT Buffer wasadded into the tube and the sample tissue was continu-ally homogenized with grinding. 20 μlofProteinaseK(10 mg/ml) was added to the sample ... the diagnosing of chronic periodontitisrelies on clinical inspection via probing depths,attachment levels, bleeding, plaque index and the use of x-rays or other radiographic methods [24]. The ... island hyper-methylation is closely linked to a variety of conditions,including tumorigenesis, chronic inflammation, and intestinal metaplasia [3].There are many key indicators of cancer, of...
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