... rho-bindingdomain. J. Biol. Chem 271, 13556–13560.15. Ishizaki, T., Maekawa, M., Fujisawa, K., Okawa, K., Iwamatsu, A. ,Fujita ,A. ,Watanabe,N.,Saito,Y.,Kakizuka ,A. ,Morii,N.&Narumiya, S. (1996) The small ... redistribution of both actin microfilaments and cytokeratin intermediatefilaments, and with the appearance of a marked cytokeratin and actin immunoreactivity at the cell junctions [28,42]. Thelatter cytoskeleton ... processes, and membrane and vesicle trafficking [2]. The molecular mechanism bywhich the small GTPases Rho-link extracellular signals totransduction pathways are of particular interest for under-standing...