... 0.05; Wilcoxon rank test). A sus-tained reduction in EDSS score of > 1 point was observed in fifteen patients (5.2%) and a sustained increase of > 1point in three patients (1%). Fatigue Overall, ... self-esteem and because, in certain countriessuch as the USA, remaining in full-time employment is animportant determinant of obtaining insurance for reim-bursement of treatment costs.Again, the ... disability, white and gray matter atrophy is arisk factor to have fatigue [31]. In additon, a recent trial of Rocca et al. using functional imaging in MS patients with fatigue and interferon beta-1a...