... subset of NSAIDs(e.g. ibuprofen, flurbiprofen, indomethacin) reducedbrain inflammation and Aβ levels in addition to the dep-osition of Aβ in brain [13,14]. Despite this evidence, and the considerable ... to the pathogenesis of AD. In the present study, we examined whether the simultane-ous administration of an anti-oxidant, vitamin E, with an anti-inflammatory drug, indomethacin, would exert an additive ... study.Eight-month-old Tg animals were divided in two groups(n = 10 each), and randomized to receive placebo, orsimultaneously indomethacin (10 mg/liter) in theirdrinking water, and vitamin...