... (http://www.cazy.org/).Amongst these enzymes, animal-type a-amylases are homologous enzymes present in all animals and insome rare bacteria [11,12]. They are nonmodular, con-sisting of a single globular catalytic ... segments.Polar versus nonpolar residuesAs far as polar and nonpolar amino acids are con-cerned, the linkers are depleted in aliphatic residues(14.4% versus 28.9% in globular proteins, Glyexcluded) ... force forfolding the connecting linkers when compared with aglobular protein. In addition, the main polaruncharged side chains (Asn, Gln, Ser, Thr) are over-represented in the linker sequences...