... monocytes, and to establish the absolute expression of mRNA and protein prior to and following stimulation with LPS. The expression of classic pro-inflammatory cytokinesand chemokines including TNF-a, ... due t o a substantial deficit in the ability of NFB to induce its own compensatory transcription in response to LPS. The expression of cytokines, chemokines and tr an- scription factors is also ... mice and IRAK4-kinase-deadknock -in mic e also fail, in vitro and in vivo,toproduceinflammatory cytokines in response to LPS and are pro-tected against LPS-induced sepsis in vivo [1 9,22-24].There...