... certain TRBJ and TRBVsegments, indicates an important role of the TRB chain in fine-tuning TR affinity of Melan-A-specific T cells of melanoma patients and argues against the hypothesis that high ... alignment of sequences, in the analysis and interpretation of data, and helped to draft the manu-script. LC, BP, PGN, and PN, have been involved in draft-ing and critically revising the manuscript. ... Mel/noM-A and Ctrl/HLA-A2+ groups. In order to obtain uniformed information, TRBV gene family and CDR3 amino acid positions were named and num-bered according to the IMGT indications http://imgt.cines.fr[55].Statistical...