Báo cáo sinh học: " Improvement of cardiac contractile function by peptide-based inhibition of NF-B in the utrophin/dystrophin-deficient murine model of muscular dystrophy" potx
Báo cáo sinh học: " Recombinant Tula hantavirus shows reduced fitness but is able to survive in the presence of a parental virus: analysis of consecutive passages in a cell culture" pot
... variantand that the lower fitness of the recombinant virus can notbe increased by pre-passaging in cell culture. The observedsurvival time of the recTULV in the presence of the Monitoring of wt and ... 3'-noncodingregion of the S segment seems to be involved in recombi-nation events, leading, however, to the deletion of the hairpin-forming sequences (A. Plyusnin, unpublishedobservations). The ... in the plus-sense RNA occur as non-pairing C/A bases in the minus-sense RNA. Interestingly, in Puumala hantavirus, a hairpin-like structure formed by a highly conserved inverted repeat in the...
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Báo cáo sinh học: " Improvement of cardiac contractile function by peptide-based inhibition of NF-B in the utrophin/dystrophin-deficient murine model of muscular dystrophy" potx
... Access Improvement of cardiac contractile function by peptide-based inhibition of NF-B in the utrophin/dystrophin-deficient murine model of muscular dystrophyDawn A Delfín1†, Ying Xu2†, Jennifer M Peterson3†, ... beyond the scope of this end-point driven study.Discussion Cardiac contractile dysfunction is one of the leadingcauses of death in DMD. Clinical treatment of thisdebilitating aspect of DMD ... through the inhibition of the NF-B signaling pathway.Lastly, we investiga ted whether NBD treatment of dkomice resu lted in an i mprovement in cardiac histopatho-logical features of this model. ...
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báo cáo hóa học:" Improvement of cardiac contractile function by peptide-based inhibition of NF-B in the utrophin/dystrophin-deficient murine model of muscular dystrophy" doc
... mice[5,6],together supporting that NBD improvement of cardiac contractile dysfunction in dko mice occurs through the inhibition of the NF-B signaling pathway.Lastly, we investiga ted whether NBD ... trans-lating the basic finding of effective NF-B inhibition into improved cardiac contractile function. We used a model of DMD that is known to have a more severe cardiac dysfunction than the mdx ... muscle contractile function in the dystrophin-deficient mdx genotypicmouse model of DMD[5,6]. This inhibition was achieved by a small, 11 amino-acid peptide named NBD (NEMOBinding Domain) that binds...
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báo cáo sinh học:" Final call for papers: "Towards a scaling-up of training and education for health workers" potx
... lack of relevance of theirtraining to community health care practice. Additionalcontributing factors include: inadequate compensationand working conditions, the deteriorating health of the workforce ... reforms had on the local health workforce?• What is the status of existing efforts to train health work-ers using innovative methods, including distance learningand various forms of information ... goals, including those contained in the Mil-lenium Declaration and those of WHO's priority pro-grammes. The health workforce crisis in developing countriesderives principally from inadequate...
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báo cáo sinh học:" "I won''''t be staying here for long": a qualitative study on the retention of migrant nurses in Ireland" ppt
... deskilling is neither in the inter-est of individual migrant nurses nor in the interest of the health systems in which they work.Respondents found that the high cost of living in Irelandalso diminished ... had been involved in the internationalrecruitment "game" for some time and were acutely aware of the need to look after their own interests and maintain the integrity of their family ... and their families, thereby ensuring the long-term integrity of the family unit:" ;The kids are not happy that we're going to move in Canada, they're very settled here, they like the...
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báo cáo sinh học:" Key factors leading to reduced recruitment and retention of health professionals in remote areas of Ghana: a qualitative study and proposed policy solutions" doc
... both the original and emer-gent themes. Transcripts were then hand-coded on the agreed dominant themes, and analyzed in duplicate, witheach analyst blind to the summary of the other. The teamthen ... we included oneadditional public, and one additional private not-for-profit hospital. The Ministry of Health sent letters of introduction,clarifying the intent of the study, to each of the ... echo the Kenyan findings.There is no large-scale experimental evidence of usingpost-graduate training as an incentive for rural service,but the Health Ministry of India launched such an incen-tive...
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báo cáo sinh học:" Thirty years after Alma-Ata: a systematic review of the impact of community health workers delivering curative interventions against malaria, pneumonia and diarrhoea on child mortality and morbidity in sub-Saharan Africa" docx
... studied[27,30]. The Navrongo and Gomoa studies in Ghanawere of small-scale CHW programmes initiated by research institutes at the time of the study [28,29]. The number of CHWs included in the studies ... ethnicity, religion.CHW TrainingDuration, methods of training (e.g. didactic/practical),site (e.g. is it near their setting of work?), choice of trainersContent of training (e.g. curative v prevent ... that the 33% reduction in child mortality alloccurred du ring the initial period of greatest investment in CHWs. After this period there was a decline in politi-cal and financial support for the...
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Báo cáo sinh học: "High ERCC1 expression predicts cisplatin-based chemotherapy resistance and poor outcome in unresectable squamous cell carcinoma of head and neck in a betel-chewing area" pdf
... 50%). The proportion score wasmultiplied by the staining intensity to obtain a finalsemi-quantitat ive H score. The median value of the Hscore was chosen as the cutoff point for separating lowand ... were thus defined as having a high expression of ERCC1. As can be seen in Table 1 a summary of result of the ERCC1 immunostaining of the cancer cells and itscorrelation with the clinicopathologic ... cause inter- and intras-trand cross-linking. These DNA cross-links arerecognized and removed by the nucleotide excision repairpathway which arms to guard the integrity of the genome[15,16]. The...
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Báo cáo sinh học: " Cytoreductive surgery plus hyperthermic intraperitoneal chemotherapy improves survival of gastric cancer with peritoneal carcinomatosis: evidence from an " pdf
... through a midlineincision of 8 cm long beginning 1 cm below the xyphoid. Once the abdominal wall was open, detailedevaluation of the PC was conducted in diff erent regionsincluding the parietal ... olled. In thisrespect, suitable animal models of PC are indispensableplatforms. Small animal models of PC have been estab-lished, including mouse models and rat models [11-18]. In most of these ... PC in this study. The animals were anesthe-tized by ear vein injection of 1% pentobarbital sodium(30 mg/kg). The abdominal skin was cleaned and disin-fect ed. Tumor cells were inject ed into...
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Báo cáo sinh học: "CGB and GNRH1 expression analysis as a method of tumor cells metastatic spread detection in patients with gynecological malignances" potx
... gonadoliberin type 1 expression levels in blood of cancer patients may allow distinguishingpatients with tumor cells circulating in their blood andindicate the metastatic spread of these cells.AcknowledgementsThis ... each other (mean: -6.56 and -3.8). The resul tsshowed that in case of CGB analysis in 95% of the popula-tion the gene expression is lower than -2.5, which indi-cates the lack of circulating ... theory is supported by the results of CGB genes silencing, showing that reduc-tion of the hormone’ sexpressionin vitro resulted in increased apoptosis rate of cancer cells [36]. Further-more elevated...
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