... MOAT-C and MRP5),a member of the ABC family of proteins, has anionC P. Wu et al. Plant polyphenols modulate MRP1, 4 and 5 FEBS Journal 272 (20 05) 47 25 47 40 ª 20 05 FEBS 47 39resveratrol, MK -57 1 and ... Modulatory effects of plant phenols on human multidrug-resistance proteins 1, 4 and 5 (ABCC1, 4 and 5) Chung-Pu Wu 1,2 , Anna Maria Calcagno2, Stephen B. Hladky1, Suresh V. Ambudkar2 and ... 21.3 141 .6 ± 30.6 157 .6 ± 48 .8 161.7 ± 50 .4 151 .5 ± 40 .8Naringenin 3 14. 4 ± 70.8 252 .3 ± 55 .0 266.9 ± 78 .4 309 ± 86 .5 338.2 ± 86.8Hesperetin 207.9 ± 51 .5 131.7 ± 19.8 200.8 ± 49 .3 162 .4 ± 34. 4 180.4...