... genomic DNA preincubated with three differ-ent concentrations (1, 50 and 150 lM) of spermine (lanes c, c¢ and c¢¢), spermidine (lanes d, d¢ and d¢¢) or putrescine (lanes e, e¢ and e¢¢) and then exposed ... NAP (s-NAP;lanes c and c¢), medium-size NAP (m-NAP; lanes d and d¢) or large-size NAP (l-NAP; lanes e and e¢) and exposed to DNase I. Controlswere the whole genomic DNA (lane a) and the DNA ... mainly spermine, can modulatethe DNA-binding properties of proteins, either increas-ing or diminishing their affinity for DNA [42]. Thisability, to modulate the DNA-binding properties ofproteins,...