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Báo cáo sinh học: " Relationship between the loss of neutralizing antibody binding and fusion activity of the F protein of human respiratory syncytial virus" doc

Báo cáo sinh học:

Báo cáo sinh học: " Relationship between the loss of neutralizing antibody binding and fusion activity of the F protein of human respiratory syncytial virus" doc

... better understand the mechanism of action of HRSV neutralizing antibodies and the impact of resistance to these antibodies upon the fusion activity of the F protein. A summary of these resultsis ... of the fusion activity of the panel of mutationsdescribed here revealed that the fusion activity of the F protein is tolerant to multiple changes in the site II and IV/V/VI region. These changes ... of changes tolerated within the F pro-tein. Although the F protein is the only virion surface pro-tein required for fusion and viral entry [25-27], the F protein is also essential for the formation...
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Báo cáo khoa học: Relationship between functional activity and protein stability in the presence of all classes of stabilizing osmolytes ppt

Báo cáo khoa học: Relationship between functional activity and protein stability in the presence of all classes of stabilizing osmolytes ppt

... leading to the preferential hydration of the protein domain is the driving force of protein stabiliza-tion or folding [3,4]. Furthermore, the effect of osmolytes on the functional activity of an enzyme ... Moosavi-MovahediAA & Ahmad F (2008) Effect of monomeric and oligomeric sugar osmolytes on DGD, the Gibbs energy of stabilization of the protein at different pH values: is the sum effect of monosaccharide ... kcat⁄ Kmvalues of all the reactions in the pres-ence and absence of all classes of osmolytes. It can beFig. 1. Effect of osmolytes on enzyme kinetic parameters. Plot of Dkcat of RNase-A versus...
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Báo cáo khoa học: Relationship between the structure of guanidines and N-hydroxyguanidines, their binding to inducible nitric oxide synthase (iNOS) and their iNOS-catalysed oxidation to NO pptx

Báo cáo khoa học: Relationship between the structure of guanidines and N-hydroxyguanidines, their binding to inducible nitric oxide synthase (iNOS) and their iNOS-catalysed oxidation to NO pptx

... >TFBGua > BuGua found for the kcat of production of NO from oxidation of these guanidines correspondswell to the order NOHA > TFBNOHG > BuNOHGfound for 1 ⁄ koffapp of the corresponding ... Kd and koff. The fol-lowing experiments were performed as a first approachto find the variation in koffas a function of the iNOSsubstrate structure.Kinetics of the binding of guanidines and N-hydroxyguanidines ... to the appearance of a differencespectrum [22,25–27]. However, the intensity of this dif-ference spectrum is small, because the spin state of the major fraction of the protein is not affected....
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Báo cáo sinh học:

Báo cáo sinh học: "Comparison between 68Ga-bombesin (68Ga-BZH3) and the cRGD tetramer 68Ga-RGD4 studies in an experimental nude rat model with a neuroendocrine pancreatic tumor cell line" ppt

... in the whole study and wrote the manuscript. LP performed the statistical analysis. MS, CW, and BW carried out the synthesis of tracers. ADS and LGS did the design of the study and revised the ... used with the reconstruction software. For the input function the mean values of the VOI data obtained from the heart were used. We used a preprocessing tool, which allowed a fit of the input ... performed for 60 min after the intravenous application of 10 to 30 MBq 68Ga-RGD4 or 20 to 40 MBq 68Ga-BZH3, using a 28-frame protocol (ten frames of 30 s, five frames of 60 s, five frames...
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báo cáo hóa học:

báo cáo hóa học: " Relationship between the EQ-5D index and measures of clinical outcomes in selected studies of cardiovascular interventions" pot

... review of the evidence on the effects and costs of implantable cardioverter defibrillator therapy in differentpatient groups, and modelling of cost-effectiveness and cost-utility for these groups ... of the models would be:Where:α0 is a fixed intercept,α1, α2 and α3 are fixed effects coefficientsβi~N(0, σβ2) are random effects allowing for different ageeffects in different ... the scales of the SAQ and the SF-6D were centred at their mean value(for age, mean age at baseline) in the models. For allexplanatory variables, a fixed effect and a Normal randomeffect was...
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Báo cáo y học:

Báo cáo y học: "Relationship between Anti-CCP Antibodies and Oxidant and Anti-Oxidant Activity in Patients with Rheumatoid Arthrit"

... inflamed, leading to swelling, pain, stiffness, and the possible loss of func-tion. Pathologically, synovial proliferation and de-struction of the articular cartilage and bone occur in the ... clear rational cut off for activity (or for normality) of ESR in RA, the usual clinical trial activ-ity cutpoints for ESR are 28–30 mm/h [19]. For that reason, a cut off value for ESR negativity ... study, we found a positive correlation between anti-CCP antibody levels and increased oxidant (MDA and MPO) activity in the synovial fluid of patients with RA. One of the end-products of lipid...
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Báo cáo y học:

Báo cáo y học: " Relationship between anal symptoms and anal findings"

... [1,2,4,6,7,14,27]. The knee-chest position may provide a better field of view than broadly used left lateral Sims’ position, as the buttocks fall to each side, and finger tips of both hands of the investigator ... skin tags and a funnel-shaped anus were highly significant (table 8). Table 8: Types and frequencies of CAF in 807 and in pa-tients with and without BAD Types of CAF Total number of patients ... least one CAF was observed in 408 of 807 pa-tients (50,6%). Such CAFs were found considerably more often in individuals with than without BAD. The differences between the BAD and the no BAD...
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Tài liệu Báo cáo khoa học: Interaction between very-KIND Ras guanine exchange factor and microtubule-associated protein 2, and its role in dendrite growth – structure and function of the second kinase noncatalytic C-lobe domain docx

Tài liệu Báo cáo khoa học: Interaction between very-KIND Ras guanine exchange factor and microtubule-associated protein 2, and its role in dendrite growth – structure and function of the second kinase noncatalytic C-lobe domain docx

... 1742α-FlagEGFP + α-FlagΔKIND2-Flagv-KIND-FlagdendriteaxonΔKIND1-FlagΔKIND1+2-FlagKIND1-FlagΔRasN-Flagα-FlagEGFP + α-FlagKIND2-FlagΔGEF-FlagABFig. 1. Domain structure of the ... 702–744 of MAP2, we performed a pull-down assay of combinations of EGFP-fused KIND1or KIND2 of v-KIND with GST-fused CD2-1-6-1 orCD2-1-6-2 of MAP2. We successfully detected a pulldown for the ... KINDPD from cerebellar lysatesPD from purified MAP2IB: α-MAP2kDa503725CBBABFig. 2. Of all members of the KIND family of proteins, only KIND2 binds to MAP2.Pull-down assay (PD) of the...
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báo cáo sinh học:

báo cáo sinh học:" A strategy to improve skills in pharmaceutical supply management in East Africa: the regional technical " potx

... managementactivities. The ability to build the skills of staff members and to hire new staff demonstrates the long-term poten-tial of the model.Following the development of the training materials and the training ... Rwanda, the RTRC is based at the School of Public Health and the Department of Pharmacy in the School of Medicine at the National University of Rwanda.Other participating departments in Rwanda ... inKenya, Rwanda, Tanzania and Uganda. These problemsranged from the inability of the existing systems to ade-quately handle scale-up programmes to lack of readiness of the workforce to efficiently...
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báo cáo sinh học:

báo cáo sinh học:" "I won''''t be staying here for long": a qualitative study on the retention of migrant nurses in Ireland" ppt

... Council of Ireland: Family Matters: Experiences of Family Reunification in Ireland. Dublin Immigrant Council of Ireland2006.34. Raghuram P: Interrogating the language of integration: the case of ... IrelandMost of the 10 respondents who planned to remain in Ire-land for the foreseeable future sought to do so becausethey felt that they and their families had settled and alsobecause they ... dependent on the employment and migration status of their spouses and children. The following discussion offers an insight into the complexweb of factors considered by respondents in decidingwhether...
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