Báo cáo hóa học: " The “Excellence in Translational Medicine” and “Bedside-to-Bench” Awards 2008-09" pptx
Tài liệu Báo cáo khoa học: The role in the substrate specificity and catalysis of residues forming the substrate aglycone-binding site of a b-glycosidase docx
... site.This hypothesis was further investigated by deter-mining the in uence on the glycone binding of the Sfbgly interactions with the aglycone. Thus, the effectof the alteration of the glycone ... b-glycosidases and in designinginhibitors. In addition, another important issue in understand-ing the aglycone specificity is the contribution of the interactions with the aglycone to the catalysis in b-glycosidases. ... the binding of the initial pentyl moiety (converting a favorable interactionto an unfavorable one). In addition, the binding energyof the terminal portion of the alkyl-type aglycone(from the...
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Tài liệu Báo cáo khoa học: The small heat shock proteins and their role in human disease pptx
... corresponding reduction in proteinstability [48,49]. However, in other studies, glycationof C-terminal lysines does not disrupt a-crystallinchaperoning [53] and activity increases when the pro-tein ... orunfavorable, depending on the disease. As a case in point, formation of huntingtin-containing inclusionbodies in Huntington’s disease encourages cell survival,whereas monomers and small inclusion bodies ... aB-crystal-lin and tubulin. Interestingly, synthesis of exogenousaB-crystallin in human lens epithelial cells hindersUVA-induced activation of the RAF ⁄ MEK ⁄ ERK sig-nal transduction pathway and...
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Tài liệu Báo cáo khoa học: "The Thesaurus in Syntax and Semantics" docx
... between the policy of interlingualizing the thesaurus, (that is, of assimilating semantics to syntax) and that of thesaurizing the syntax (that is, of in- cluding syntax within semantics) the linguists ... separation of the particular from the comparative universal range of validity (in MT terminology, of monolingual from interlingual features), and by their separate handling in the program The basic ... chine, a sentence could be translated with com- plete syntactical correctness from Japanese into the interlingua, and from the interlingua into English, German, Latin and Welsh. Thus the...
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Báo cáo khoa học:The principle of flux minimization and its application to estimate stationary fluxes in metabolic networks docx
... down-regulated in the anucleated erythrocyte) and the substrates fuelling the reaction are both p resent. On the other hand, despite some s ystematic differences to the r esults of kinetic modelling, the ... lactate. There is nothermodynamic or kinetic principle excluding the existenceof such a h ypothetical g lucose-wasting and p yruvate-utilizing metabolic regime . However, the flux-minimizationprinciple ... v1¼1.51 mMÆh)1. The las t two c olumns of Table 1 contain the flux values obtained by the flux-minimization methods and by kinetic m odelling. The correlation between these inde-pendent sets...
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Báo cáo khoa học: The role of helix 8 and of the cytosolic C-termini in the internalization and signal transduction of B1 and B2 bradykinin receptors potx
... determined in the presence of 5 lm unlabeled agonist and subtracted from the total binding to calculate the spe-cific binding.Internalization of [3H]BK and [3H]DAKTo determine the internalization ... 2004 FEBS The role of helix 8 and of the cytosolic C-termini in the internalization and signal transduction of B1 and B2bradykinin receptorsAlexander Faussner1, Alexandra Bauer1, Irina Kalatskaya1, ... agonist[20]. As the internalization is expressed in percentageof total binding, decreasing the binding affinity of the Role of helix 8 and C-termini in bradykinin receptors A. Faussner et al.130 FEBS...
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Báo cáo khoa học: The propeptide in the precursor form of carboxypeptidase Y ensures cooperative unfolding and the carbohydrate moiety exerts a protective effect against heat and pressure pot
... that the cleft of the active site will be located in the interface between the two structural domains of CPY and would be filled by the propeptide, thus uniting the two domains in a body, as if the ... perturbed by the carbohydrate moiety, thusincreasing their fluorescence, since they are in close proximityto the carbohydrate-attachment sites, N13, 87, and 368. In conclusion, the mature enzyme, ... would be composedof a single fragile domain. The propeptide of the proenzymewould be located at the interface of the two domains thuscombining them into one body, to ensure structuralcooperativity.AcknowledgementsWe...
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Báo cáo khoa học: The Rab5 effector Rabaptin-5 and its isoform Rabaptin-5d differ in their ability to interact with the small GTPase Rab4 doc
... Rabaptin-5 in the pPC86 vector and the Fig. 9. Mapping of the Rab4 binding site in Rabaptin-5 using the yeast two-hybrid protein–protein interaction assay. Indicated frag-ments of Rabaptin-5 ... chain and the Rab4 binding site of Rabaptin-5 arelocated in the N-terminal portion of protein. However,some discrepancy exists in the literature concerning the position of the Rab4-binding site. ... containing KpnI and BglII sites, and subclonedbetween the KpnI and HindIII sites of pBluescriptSK II(+) vector using the internal HindIII site (plasmidp5Rn5). The 3¢-end of the Rabaptin-5 coding...
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Báo cáo khoa học: The role of residues R97 and Y331 in modulating the pH optimum of an insect b-glycosidase of family 1 pdf
... [10,12].Nevertheless, it is not possible to assume that the same isoccurring in the mutant R97M, because there is no data on the interactions between the substrate and the arginineresidue.Finally, another ... mMBicine buffer 7.0–8.5). The pH stability of Sfbgly50 was checked by incubation in the same buffers for a time equal to the assay time and thendetermining the activity remaining at the optimum ... resultfrom the modifications in the interactions between the catalytic glutamates and the residues R97 and Y331,indicating that these residues play a role in the modulationof the Sfbgly50 pH optimum.Sequence...
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Báo cáo y học: " Regional coordination in medical emergencies and major incidents; plan, execute and teach"
... [10]. The informa-Shows the gold command and control roomFigure 1Shows the gold command and control room.Gold command and control centre in actionFigure 2Gold command and control centre in action.BioMed ... anesthesiolo-gist with training in disaster medicine) was created. In this24/7 system, the RTiB is the POC for the healthcare facili-ties within the region and has the mandate to act as "GoldControl," ... ofthem teenagers. The following investigation revealed cer-tain short-comings regarding the medical response, recog-nizing the need of a regional point of contact ("POC") and command...
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Báo cáo y học: "The association of meat intake and the risk of type 2 diabetes may be modified by body weight"
... anthropometrics and other lifestyle factors. Protocols for the SWHS were approved by the Institutional Review Boards of all institutes involved in the study. Dietary intake and other exposure information ... disease between the baseline and follow-up FFQs, only dietary data from the baseline FFQ were included in this analysis. For other participants the average of the baseline and follow-up FFQ ... as walking, stair climbing, cycling, household activities and daily commuting to and from work (walking and cycling). We calculated the metabolic equivalents for each activity, using a compendium...
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Từ khóa: chuyên đề điện xoay chiều theo dạngNghiên cứu tổ chức pha chế, đánh giá chất lượng thuốc tiêm truyền trong điều kiện dã ngoạiNghiên cứu vật liệu biến hóa (metamaterials) hấp thụ sóng điện tử ở vùng tần số THzNghiên cứu tổ chức chạy tàu hàng cố định theo thời gian trên đường sắt việt namGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitĐỒ ÁN NGHIÊN CỨU CÔNG NGHỆ KẾT NỐI VÔ TUYẾN CỰ LY XA, CÔNG SUẤT THẤP LPWANNGHIÊN CỨU CÔNG NGHỆ KẾT NỐI VÔ TUYẾN CỰ LY XA, CÔNG SUẤT THẤP LPWAN SLIDEPhát triển mạng lưới kinh doanh nước sạch tại công ty TNHH một thành viên kinh doanh nước sạch quảng ninhSở hữu ruộng đất và kinh tế nông nghiệp châu ôn (lạng sơn) nửa đầu thế kỷ XIXChuong 2 nhận dạng rui roQuản lý nợ xấu tại Agribank chi nhánh huyện Phù Yên, tỉnh Sơn La (Luận văn thạc sĩ)chuong 1 tong quan quan tri rui roNguyên tắc phân hóa trách nhiệm hình sự đối với người dưới 18 tuổi phạm tội trong pháp luật hình sự Việt Nam (Luận văn thạc sĩ)Giáo án Sinh học 11 bài 14: Thực hành phát hiện hô hấp ở thực vậtGiáo án Sinh học 11 bài 14: Thực hành phát hiện hô hấp ở thực vậtChiến lược marketing tại ngân hàng Agribank chi nhánh Sài Gòn từ 2013-2015Đổi mới quản lý tài chính trong hoạt động khoa học xã hội trường hợp viện hàn lâm khoa học xã hội việt namQUẢN LÝ VÀ TÁI CHẾ NHỰA Ở HOA KỲ