... shown that selected sigma-2ligands are capable of inducing apoptosis in a multitude of human and murine cancer cells lines and in animalmodels of cancer including pancreas cancer [12,13,15].The ... representing standard error of the mean.The sigma-2 ligand, SV119, combined with gemcitabine sup-presses tumor growth and increases survival in model pan-creatic adenocarcinoma in vivoFigure ... wasobtained from Bryan Clary (Duke University) and main-tained in supplemented RPMI 1640 containing glutamine(2 mmol/L), pyruvate (1 mmol/L), penicillin (100 IU/mL), streptomycin (100 IU/mL), and...