báo cáo hóa học:" Increased immunogenicity of surviving tumor cells enables cooperation between liposomal doxorubicin and IL-18" ppt

... 1 of 9(page number not for citation purposes)Journal of Translational MedicineOpen AccessResearch Increased immunogenicity of surviving tumor cells enables cooperation between liposomal doxorubicin ... subpopulations of immune cells of the adaptive and innate immune system.It activates effector T cells; induces IFN-γ, TNF-α, IL-1α, and GM-CSF production; promotes Th1 differentiation of naive T cells; and ... mole-cules, and modulating death receptors and other immu-nomodulatory ligands. Accordingly, investigation isrequired to elucidate mechanisms that both increase the immunogenicity of tumor cells surviving...

Báo cáo hóa học: " Increased shedding of HU177 correlates with worse prognosis in primary melanoma" pdf

... limitation of current in vitro and in vi vo models is that they oftenoverlook the contribution of the ECM and the tumor microenvironment toward the initiation and progress ion of tumorigenesis. ... increased angiogenesis and tumor growth in vivo [9]. We have successfully developed anELISA assay to detect and quantify levels of cryptic epi-tope HU177 in the serum of melanoma patients and demonstrated ... Kreutz M, Dettmer K, Oefner PJ,Bosserhoff AK: Direct and tumor microenvironment mediated influences of 5’-deoxy-5’-(methylthio)adenosine on tumor progression of malignantmelanoma. J Cell Biochem...

báo cáo hóa học: " Increased levels of HMGB1 and pro-inflammatory cytokines in children with febrile seizures" pot

... 2 Correlation between serum cytokine levels in seizure patients. (A-D) Correlation between serum levels of IL-1b and HMGB1 (A), IL-1b and IL-6 (B), IL-1b and TNF-a (C), and IL-6 and TNF-a (D) ... ± standard error of meanChoi et al. Journal of Neuroinflammation 2011, 8:135http://www.jneuroinflammation.com/content/8/1/135Page 4 of 9RESEARCH Open Access Increased levels of HMGB1 and ... Tehranian R, Iverfeldt K, Winblad B, Schultzberg M: Increased expression of mRNA encoding interleukin-1beta and caspase-1, and thesecreted isoform of interleukin-1 receptor antagonist in the rat...

báo cáo hóa học:" Preclinical evaluation of dasatinib, a potent Src kinase inhibitor, in melanoma cell lines" pptx

... 2Comparison of IC50 concentrations of temozolomide when tested alone and in combination with dasatinib in HT144, Lox-IMVI, Malme-3M and Sk-Mel-28 cells. Standard deviations represent average results of ... cycle arrest. Effect of dasatinib on cell cycle arrest. Comparing the effect of dasatinib versus untreated cells on the percentage of cells tested in the G1, S and G2/M phases of cell cycle.Click ... migration and invasion in human melanoma cell lines. Expression and activation of Src kinase, FAK and EphA2 were also examined in the melanoma cells. Results: Dasatinib inhibited growth of three of...

báo cáo hóa học:" Vasoprotective effects of human CD34+ cells: towards clinical applications" pptx

... derived progenitor cells (hemato-poetic progenitor cells, HPCs) and microvascularendothelial cells in bone marrow. Endothelial cells appearto regulate the trafficking and release of HPCs from bonemarrow ... ±0.18, and 1.71 ± 0.18 for CD34, and saline-treated vessels,Characterization of human CD34+ cellsFigure 1Characterization of human CD34+ cells. A. Scatter analysis reveals a low side scatter and ... microvascularendothelial cells, and this shared antigen expression between microvascular endothelium and hematopoieticprogenitors is also strongly supportive of a shared embry-ological origin and that hematopoiesis...

Báo cáo hóa học: " Molecular signatures of maturing dendritic cells: implications for testing the quality of dendritic cell therapies" pptx

... global changes of both gene and miR expres-sion associated with LPS and IFN-g induced DC matura-tion. Gene and miR changes in DCs were assessed aft er4, 8 and 24 hours of LPS and IFN-g stimulation. ... 24 hours of maturation with a 37-fold and 21-fold increase respectively. The expression of thecell cycle and cell signaling genes GADD45A and RGS1also increased most after 24 hours of maturation. ... analysis of maturingDCs revealed two distinct patterns: down-regulation of groups of miR at 8 hours of maturation with sustainedlow expression throughout the rest of maturation and up-regulation of...

báo cáo hóa học: " The impact of itch symptoms in psoriasis: results from physician interviews and patient focus groups" pdf

... areas of clinical concern; and 3) explore pso-riasis patients' perceptions of the impact of psoriasis. Ful-fillment of these objectives will satisfy the first component of the U.S. Food and ... open-ended and closed-ended questions.Four of the clinicians had over 10 years of experience, and one clinician had 7 years of experience. Four of the clini-cians practiced medicine in a research and ... patients'identification of stress as an aggravating factor for itch and the negative impact of itch on sleep [19,22]. The results of these studies confirm the link between the impact of pso-riasis symptoms and...

báo cáo hóa học: " A comparison of EQ-5D index scores using the UK, US, and Japan preference weights in a Thai sample with type 2 diabetes" pdf

... d ±1.96*SD of d.The Bland-Altman plot of UK and US weights showed that96.4% of the difference scores were between the limits of agreement, 3.3% below the lower agreement line, and 0.3% above ... magnitudes of correlation between the Japan weighted scores and these variables were higherthan those between both UK and US weighted scores and these factors. The magnitudes of correlation between ... 5:.Health and Quality of Life Outcomes 2008, 6:71 http://www.hqlo.com/content/6/1/71Page 5 of 9(page number not for citation purposes)The Bland-Altman plot of UK and Japan weights showedthat 96% of...

báo cáo hóa học: " The effect of pharmacological treatment on gait biomechanics in peripheral arterial disease patients" pptx

... alterations on the biomechanics of gait of the PAD patients as revealed by the statistical comparisons performed between pre and post-treatment and between post-treatment and the healthy controls.Conclusions: ... PADpatients between pre- and post- pharmacological treat-ment (Table 3).DiscussionThe purpose of this study was to determine the impact of pharmacological treatment on the biomechanics of gait of PAD ... mean values are in degrees of motion. AROM - Ankle range of motion; KROM - Knee range of motion; HROM - Hip range of motion.Huisinga et al. Journal of NeuroEngineering and Rehabilitation 2010,...

báo cáo hóa học: " ELISA measurement of specific non-antigenbound antibodies to Ab1-42 monomer and soluble oligomers in sera from Alzheimer’s disease, mild cognitively impaired, and noncognitively impaired subjects" pptx

... the standard curveOD reached 1.0. Softmax Pro softwar e version 3.0(Molecular Devices) was used to generate the best-fitplot of the standard curve, using the log-logit option.Calculation of ... theassociation between antibody concentrations to A bmonomer and oligomeric Ab using pooled data from allgroups and also within each group. Differences in meanantibody levels between groups and between ... repeated mea-sures ANOVA. The standard deviat ion of concentration and the mean concentration of anti-Ab antibodies inNCI sera (averaged between dissociated and undisso-ciated samples) were...

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