báo cáo hóa học:" Development of targeted therapy for ovarian cancer mediated by a plasmid expressing diphtheria toxin under the control of H19 regulatory sequences" doc
... that
the DTA -H19 construct has a high therapeutic potential
and is a very promising candidate for ovarian cancer ther-
apy in humans.
Materials and methods
Cell culture
The human ovarian carcinoma ... effective anti-
tumor agents. Various gene therapy strategies for the treat-
ment of ovarian cancer are currently under development
and aim towards maximal trea...
... article as: Amit and Hochberg: Development of targeted
therapy for bladder cancer mediated by a double promoter plasmid
expressing diphtheria toxin under the control of H19 and IGF2-P4
regulatory ... healthy mice were used as control. The total tumor area of each bladder was determined and
the mean of the total areas was calculated for each g...
... of the paper. All authors
read and approved the final manuscript.
Additional material
Acknowledgements
This study was funded by the State of California, Department of Public
Health through the ... particular to Michele Carter, RN, of UCLA, and
Monica Moore, MSG, of the Alzheimer's Association California Southland
Chapter. Other agencies that provided invaluable a...
... or pair housed and cared for according to the
American Association for Accreditation of Laboratory
Animal Care guidelines. The Wyeth Institutional Animal
Arai et al. Journal of Translational Medicine ... required upon hand-off
for assay validation. SJ, AW, SWA and KA performed the in vitro assays on mon-
keys treated with Ab-01 and control Ig and analyzed the data, and KA...
... respiratory disease and help to understand
the impact that COPD and asthma have on outcomes
related to sleep.
Abbreviations
ALIS: Asthma Life Impact Scale; ANOVA: Analysis of vari-
ance; AQLQ: Asthma ... clinician-rated and patient-
rated severity, overall health, and exacerbation status for
patients with asthma. The ability of the CASIS to differen-
tiate by disease severity an...
... other
comorbidities, and the utilization of health care and
non-health care resour ces, laboral status and a stimated
cost of the fibromyalgia impact during the year before.
An eva luation was also made of patient ... CLINISAS, Madrid), I Vallejo (Hospital
Clinic, Barcelona), J Vidal (Hospital General, Guadalajara). Milena Gobbo and
Unidad de Investigación de la Fundación Españo...
... properties
of both the total as w ell as domain subscale scores and
the data from the validation study supports the claims
for reliability and validity for both. As a result, each
domain subscale can ... believe the bias introduced
by a web-based study to be minimal, given the preva-
lence of computer access now available in the U.S., U.K.,
Canada and Australia. Al...
... sample size
needed for purposes of evaluation. The denominator was
the standard deviation of the score changes for those
patients in the test-retest analysis.
Health and Quality of Life Outcomes ... to as the KQoL-26, are computed by summing the
items where half or more are completed for the relevant
scale and transforming to a 0–100 scale. The scores were
appr...
... was undertaken using the time
trade-off (TTO) technique where individuals are asked to
undertake conventional TTO valuations for a sample of
health states. The Measurement and Valuation of Health
(MVH) ... exercise. *DM ran
the analysis to identify items for the valuation exercise,
analysed the validation data and contributed to the writ-
ing of the manuscript. JB de...
... of the
study, collected the data and performed the statistical
analysis BD and VM: participated in the design of the
study, collected medical data and participated to the inter-
pretation of data ... consist-
encies.
Construct validity
- Factor analysis
The factor analysis with varimax rotation identified a
structure of five factors, which accounts for 46.3% of th...