báo cáo hóa học:" Phase I/II open-label study of the biologic effects of the interleukin-2 immunocytokine EMD 273063 (hu14 18-IL2) in patients with metastatic malignant melanoma" docx
... biologic effects of the
interleukin-2 immunocytokine EMD 273063 (hu14. 18-IL2) in
patients with metastatic malignant melanoma
Antoni Ribas
1
, John M Kirkwood
2
, Michael B Atkins
3
, Theresa ... response. The main finding of this study was an
increase in intratumoral CD8+ CTL with possible
increased expression of CD3zeta and granzyme B after
adminis...
... 0.0206).
Discussion
This study established the safety and feasibility of com-
bining vaccination with MVA expressing 5T4 and high-
dose IL-2 in patients with metastatic RCC. The trial was
Table 3: ... Yang JC, White DE, Steinberg SM: Durability of
complete responses in patients with metastatic cancer
treated with high-dose interleukin-2: identification of the...
... were
induced with the gp100 -in4 stimulation on the PBMCs
taken from the patients (P1, P2, P3, and P4) after the
vaccination. The PBMCs of P1 showed an incremental
increase in the frequency of induced ... IFN-g-producing
cells in association with the number of the vaccinations.
In P2, a significant increase of the frequency of induc-
tion of IFN-g-pro...
... was
involved in the tumor sample collection. AVH and MR
were involved in the statistical analysis of the data. JN, GG
and MS were involved in the data collection of the
patients, and in the review ... removed from the
training set. The other samples are reduced to those 50
genes with the highest signal-to-noise ratio, which are
used as a training set in a tr...
... anti-inflammatory property targeting at
different levels of TNF-α activity. The anti-inflammatory role of ginseng may be due to the
combined effects of ginsenosides, contributing in part to the ... present in significant concentrations may modulate
the activity of the ginsenosides.
We then investigated the combinatorial effect of the nine
ginsenosides on TNF-α in...
... data was obtained using the summary
PROF, PROFAD and SSI indices. Principal component
analysis was used to investigate the internal structure of
the PROFAD-SSI. Facet scores rather than individual ... design of the study. FV
participated in the design of the study. NM participated in
the design of the methodology, managed data collection,
conducted some of the...
... health-related quality of life.
HRQOL is defined as the perception of overall satisfaction
with life and involves the measurement of functional sta-
tus in the domains of physical, cognitive, ... rate during the submaximal graded exercise test,
or were missing any data required for the analysis. Any
participant who reported smoking on the morning of the
HFA was exc...
... erval, by analogy to
theconstraintinducedbyametronome;2)thatTW
may increase the local dynamic stability of walking, due
to the diminution of degrees of freedom in the more
constrained artificial e ... exponent
requires intensive computing power, 7 min of the
10 min walking test (from 1.5 to 8.5 min.) was selected
and the raw data were down-sampled to 100 Hz. The
determin...
... the stance phase (the phase in which the foot is
on the ground). Others use the energy from the bending
of the shoe sole. In both cases, the device aims to use
the energy that would otherwise have ... However, there
were certain d rawbacks associated with this device in
that it used only a small part of the motion of the knee
(end of the swing phase...
... forward, thereby
preventing over-recognition when user is talking to some-
one. Plus the direction of the IW is determined by the
inclination of the user's face instead of the direction of the
user's ... abilities, the proposed system involves the
use of face-inclination and mouth-shape information, where the direction of an IW is determined
by the in...