báo cáo hóa học:" Drugs targeting the mitochondrial pore act as citotoxic and cytostatic agents in temozolomide-resistant glioma cells" pptx
báo cáo hóa học:" Drugs targeting the mitochondrial pore act as citotoxic and cytostatic agents in temozolomide-resistant glioma cells" pptx
... containing the MPT-inducing drugs at the d esired concentration,was added to the cells.- Annexin V binding assayBased on the phenomenon that phospholipids (PS) areexposed during apoptosis and ... AM staining. Apoptosis has been assayed by Hoechstincorporation and Annexine V binding assay. Authophagy has been tested by acridine orange staining.Results: We performed a molecular and genetic ... the contact sitebetween the inner and outer mitochondrial membranes. The composition of the MPTP is still unknown and results from the association of several proteins. Amongthem, the adenine nucleotide...
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báo cáo hóa học: " Comparison of the discriminative ability of a generic and a condition-specific OHRQoL measure in adolescents with and without normative need for orthodontic treatment" potx
... the IOTN.For example, DAI includes number of missing visibleteeth, crowding in the incisal segments, spacing in the incisal segment, and measurement of any midlinediastema that are not specifically ... during the last6 months was self-reported by the participants. Informa-tion about oral impacts was collected using OHIP-14 and OIDP. Adolescents self-completed OHIP-14 in their class-rooms and ... scored. If no impact was reported, then a zeroscore was assigned. Thereafter, adolescents were asked toidentify from a list those oral problems that, in their opin-ion, caused the impact. Only those...
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báo cáo hóa học: " Replication of the association of HLA-B7 with Alzheimer''''s disease: a role for homozygosity?" pptx
... cohorts involved in the study [9], it remains possible that these contrasts weredue to geographical differences, for instance in the finestructure of linkage disequilibrium or in interactions ... region and on search strat-egies in the region; MB supervised the HLA genotyping and was responsible for quality control; IQ and AS per-formed the HLA genotyping; DRW isolated the DNA and performed ... alleles in linkage disequilibrium with each other,HLA-B7 and HLA-Cw*0702, especially in people without the ε4 allele of apolipoprotein E (APOE4). As that associ-ation was not replicated in two other...
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Tài liệu Báo cáo khoa học: Role of the cag-pathogenicity island encoded type IV secretion system in Helicobacter pylori pathogenesis pptx
... aphosphorylation-dependent fashion: the tyrosine phos-phatases Shp1, the adaptor proteins Grb2, Grb7 and Crk, phosphoinositide-3-kinase, Ras GTPase activatingprotein RasGAP, and as well as the tyrosine kinases,Csk, ... vinculin and ezrin, which are three well-known actin-binding proteins [6]. The phosphatasesinvolved in this scenario, however, remain unknown and do not require Shp2. Instead, CagAPYcan inhibitSrc ... CagA-independent pathways involved in the activation of receptor and non-RTKs, pro -in ammatory signalling, RhoGTPase activation, scattering and motility of gastric epithelial cells, as well as the...
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báo cáo hóa học:" RAGE (Receptor for Advanced Glycation Endproducts), RAGE Ligands, and their role in Cancer and Inflammation" pptx
... proliferation,migration, invasion, and activates the MAP kinase and NFκB pathways [149]. The anti-allergy drug cromolynbinds S100P and will block S100P-RAGE interaction. Itinhibits tumor growth and increases the ... to inhibit RAGE activation and, in the setting of cancer, tumorigenesis. RAGE is the link betweeninflammatory pathways and pathways promoting tumor-igenesis and metastasis. Characterizing the ... systemic inflammation, and therebydecreases insulitis [176]. Aminoguanidine delivery alsodecreases levels of albumin in the blood stream and decreases aortic and serum levels of AGEs thus slowing the progression...
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Báo cáo hóa học: " Effects of a robot-assisted training of grasp and pronation/supination in chronic stroke: a pilot stud" pot
... facilitated increased use of the impaired hand to perform daily tasks, as could the reduction in pain levels in the two subjects who initially presented with minimal pain. Robot-assisted training may ... subjects were asked to relax and apply minimal grasping force. An audio signal indicated the beginning of the closing phase, which required the subject to actively flex the fingers against a resistive ... by the robot during the exercise in order to require the subject to hold the knob firmly during the movement. During training, interactive and intuitive visual feedback was provided to the...
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Báo cáo hóa học: " Accelerometer-based wireless body area network to estimate intensity of therapy in post-acute rehabilitation" pptx
... on the limbs) and Others (all other activities thatdoes not fit in any of the other 7 categories).For each activity, the observer classifies the time spent by the patient as active time or passive ... contactwith the patient in the therapy unit. The therapy was con-ducted by the clinicians without any intervention from the observer.Participants were evaluated prior to the beginning of the observations ... time. Active time isdefined as the time during which the patient is physicallyactive, in preparation or execution of a task-orientedaction. The patient does not have to be in company of the therapist....
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Báo cáo khoa học: Inhibition of the mitochondrial calcium uniporter by the oxo-bridged dinuclear ruthenium amine complex (Ru360) prevents from irreversible injury in postischemic rat heart docx
... phosphohydro-lase total activity in the mitochondrial fraction and nocontaminant activity of cytochrome c oxidase in the microsomal fraction. In addition, in the microsomalfraction, 329.3 nmolÆmg)1Æmin)1of ... 5¢-ribonucleotidephosphohydrolase activity was found vs. 20.4 nmolÆmg)1Æmin)1 in the mitochondrial fraction, indicatingsarcolemmal contamination in the microsomal fraction. The discrepancy between our binding results ... polyethylenimine and washed twice with cold washing buffer (10 mm Hepes,100 mm KCl, pH 7.4). Radioactivity retained in the filterswas measured in a scintillation counter and nonspecific bind-ing was determined...
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báo cáo hóa học:" Validation of a flow cytometry based chemokine internalization assay for use in evaluating the pharmacodynamic response to a receptor antagonist" potx
... concentration of CCR2inhibitor examined the % CV was 13.3% and thereforesince the %CV was never greater than 20%, the sensitivityof the assay was determined to be the lowest titrationpoint (0.005 μg/ml) ... titrated into the assay using the derived optimum AF488-MCP-1 concen-tration and an inhibition curve was generated. As shown in figure 2b, the CCR2 antagonist was able to inhibit the internalization ... -70°C, was determined in the whole blood internalizationassay by performing the assay on 4 different volunteers(differing at each time point) over a period ending at 26weeks. The baseline value...
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báo cáo hóa học:" Summary of the primer on tumor immunology and the biological therapy of cancer" ppt
... aviditytumor-reactive CD8+ T cells in individual patients in time and maintain their survival in vivo. The solution is genetherapy, by engineering T cells with high avidity throughinsertion of ... presentedwork using anti-CTLA-4 Ab alone or in combination withother modalities to treat murine tumors. Activation of vas-culature in tumors, extravasation and proliferation of Tcells, and increased ... exist). Both angiogenesis and vasculogene-sis play roles in the formation and maintenance of tumorvasculature and the progression of cancer. VEGF and PDGF bind their corresponding receptors to trigger...
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Từ khóa: Nghiên cứu sự biến đổi một số cytokin ở bệnh nhân xơ cứng bì hệ thốngNghiên cứu sự hình thành lớp bảo vệ và khả năng chống ăn mòn của thép bền thời tiết trong điều kiện khí hậu nhiệt đới việt namMột số giải pháp nâng cao chất lượng streaming thích ứng video trên nền giao thức HTTPNghiên cứu tổ chức chạy tàu hàng cố định theo thời gian trên đường sắt việt namGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitGiáo án Sinh học 11 bài 13: Thực hành phát hiện diệp lục và carôtenôitPhát triển du lịch bền vững trên cơ sở bảo vệ môi trường tự nhiên vịnh hạ longNghiên cứu, xây dựng phần mềm smartscan và ứng dụng trong bảo vệ mạng máy tính chuyên dùngNghiên cứu về mô hình thống kê học sâu và ứng dụng trong nhận dạng chữ viết tay hạn chếNghiên cứu khả năng đo năng lượng điện bằng hệ thu thập dữ liệu 16 kênh DEWE 5000Tìm hiểu công cụ đánh giá hệ thống đảm bảo an toàn hệ thống thông tinThơ nôm tứ tuyệt trào phúng hồ xuân hươngChuong 2 nhận dạng rui roKiểm sát việc giải quyết tố giác, tin báo về tội phạm và kiến nghị khởi tố theo pháp luật tố tụng hình sự Việt Nam từ thực tiễn tỉnh Bình Định (Luận văn thạc sĩ)BT Tieng anh 6 UNIT 2Giáo án Sinh học 11 bài 15: Tiêu hóa ở động vậtGiáo án Sinh học 11 bài 15: Tiêu hóa ở động vậtTrách nhiệm của người sử dụng lao động đối với lao động nữ theo pháp luật lao động Việt Nam từ thực tiễn các khu công nghiệp tại thành phố Hồ Chí Minh (Luận văn thạc sĩ)Đổi mới quản lý tài chính trong hoạt động khoa học xã hội trường hợp viện hàn lâm khoa học xã hội việt namHIỆU QUẢ CỦA MÔ HÌNH XỬ LÝ BÙN HOẠT TÍNH BẰNG KIỀM