báo cáo hóa học:" High correlation of the proteome patterns in bone marrow and peripheral blood blast cells in patients with acute myeloid leukemia" pot

... represented in the AML samples.Intra-individual analysis of the spot patterns showed a high correlation between the sample from peripheral blood and bone marrow (Table 2). On/off-phenomena of the identified ... 2Detail of the two-dimensional patterns of patient A. Detail of the two-dimensional patterns of patient A. Different expression of spot 19 (annexin 6) in the bone marrow sample in comparison to peripheral ... to investigate the profile of protein expression of blast populations from peripheral blood and bone marrow aspirates using a proteomicapproach with 2D-electrophoresis in newly diagnosedpatients...

báo cáo hóa học:" Heterogeneous activation of the TGFβ pathway in glioblastomas identified by gene expression-based classification using TGFβ-responsive genes" pptx

... shown in box plots. Y-axis is the expression level of SERPINE1 in log2 scale. The black arrow indicates the mean expression level of SERPINE1 in each type of gliomas. Red spots indicate the ... initiates the intracellular signaling cascadeinvolving the SMAD, a family of proteins similar to the gene products of the Drosophila gene "mothers againstdecapentaplegic" (Mad) and the ... anti-TGFβ therapies in these two distinct subgroups of glioblastomas patients. BackgroundGlial tumors are the most common primary brain malig-nancies in adults. In the United States, they result in...

báo cáo hóa học:" Molecular analysis of the apoptotic effects of BPA in acute myeloid leukemia cells" potx

... considered independently of its ED action and mighthelp in the understanding of the adverse effects caused in humans.AbbreviationsAKT: RAC-alpha serine/threonine-protein kinase; AML: Acute Myeloid ... EN, VS,GDM and AM contributing in performing the experimentsshown and in the conceptual understanding of the results.PB and LA critically discussed the experimental data and wrote the manuscript.Acknowledgements In ... the double treatment, showing an increase of the G1 peack at low dose BPA (30 μM) and an increase of the G2-M fraction of cells at the highest concentration of BPA (100 μM). Differently, in the...

báo cáo hóa học:" Epigenetic control of the ubiquitin carboxyl terminal hydrolase 1 in renal cell carcinoma" doc

... during the differentiation of renal tubules representing the origin of clear cell renal cell carcinoma (RCC) and in the regula-tion of the cell cycle of parietal epithelial cells of the Bow-man's ... of the UCHL1 promoter DNA in the RCC cellline MZ2862RC, characterized by methylation of some of the CpG dinucleotides within the core region of the UCHL1 promoter while other CpG sites remain ... in the development of resistance against chemo-therapy and radiation in cancer cells, the determination of the given methylation status of the UCHL1 promoter maycontribute to the understanding...

báo cáo hóa học:" Optical imaging of the peri-tumoral inflammatory response in breast cancer" docx

... several of the in vitroexperiments. SAK was involved in data analysis and wrotepart of the manuscript. CA and VR gathered a portion of the in vitro data. FVC was the primary investigator on the T32 ... the T32 training grant and edited the manuscript. LMC was the primary investigator on the NIH grants and Depart-ment of Defense grant listed in the acknowledgementssection and was involved in the ... competing interests.Authors' contributionsAKS conducted or took part in all the experiments and was the primary writer of the manuscript. RJK was involved in the in vivo data gathering....

Báo cáo hóa học: "High activity of sequential low dose chemo-modulating Temozolomide in combination with Fotemustine in metastatic melanoma. A feasibility study" pptx

... thrombocytopenia) with a dosereduction in 4 patients in cohort A and in only2 patients in cohort B, and chemotherapy delayed in 4 p atients in cohort A and in 2 patients in cohort B. In summary, the d1-21 ... occurred in both cohorts of patients (in 4 and 5 patients respectively).Other minor side effects included nausea-vomitinginvolving about 50% of patient in both cohorts, transa-minase increase in ... carried out the coordination of the study and drafted the manuscript.All authors read and approved the final manuscript.Competing interests The authors declare that they have no competing interests.Received:...

Báo cáo hóa học: " High expression of transcriptional coactivator p300 correlates with aggressive features and poor prognosis of hepatocellular carcinoma" doc

... YC, JHH and QLWparticipated in the data analysis and interpretation. All authors read and approved the final manuscipt.Competing interests The authors declare that they have no competing interests.Received: ... tissues. According to the ROC curves, the cutoff score for p300 high expression was defined when more than 60% of the tumor cells were positivelystained. High expression of p300 was examined in 60/123 ... temperature, and stained with DAB (3,3-diaminobenzidine). Finally, the sectionswere counterstained with Mayer’ s hematoxylin, dehy-drated, and mounted. A negative control was obtainedby replacing the...

báo cáo hóa học: " Factor structure of the Hospital Anxiety and Depression Scale in Japanese psychiatric outpatient and student populations" pdf

... identify the confounding factors of item 10.Despite these minor shortages, the scoring system of the HADS should adhere to the original instructions by Zig-mond and Snaith [1]; the HADS-A and HADS-D ... mentioned. The revision of the HADSshould be started from such language issues in advance of the rescoring. In the original scoring system, however, the two of the depression items (item 6 and 10) ... showed higher load-ings on the anxiety factor and the item 7 indicated higherloading on the depression factor, these inappropriateloadings appear to be stemmed partly from the wordingissues...

báo cáo hóa học: " Telephone reliability of the Frenchay Activity Index and EQ-5D amongst older adults" pptx

... telephone and face-to-face administration of these instruments at both the individual item level and overall score. Within the EQ-5D instrument, the intraclass correlation coefficients and limits of ... reliability study of the Barthel Index, the Rivermead Mobility Index, the Notting-ham Extended Activities of Daily Living Scale and the Frenchay Activities Index in stroke patients. Disability and reha-bilitation ... telephone administration of these instruments is a valid method of obtaining thisinformation from elderly patients in the community. The ability to collect this survey based information via the tel-ephone...

báo cáo hóa học: "Rasch analysis of the Multiple Sclerosis Impact Scale (MSIS-29)" pot

... according to anumber of parameters, including the degree of requiredprecision of the person and item estimates, and the target-ing of the sample. A well targeted sample is one in which the person ... divergent validity using Raschcalibrated interval level scale scores [23]. With the increasing use of the MSIS-29 in research in many parts of the world further analysis of the scale's psy-chometric ... further evidence for the internal validity of the physical and psychological impactscales of the MSIS-29, supporting their use in clinical and research settings as a measure of HRQoL to augment...

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