... Biotechnology InstituteSan AntonioVitoria, SpainEduardo Anitua, DDS, MDScientific director of BTI Biotechnology InstitutePrivate Practice in Vitoria (Spain)San AntonioVitoria, SpainPaulo M. Camargo, ... contribute to increasedplaque accumulation. Deep, sharp clefts, andmarked soft tissue marginal discrepancies in ad-jacent areas have been implicated as factors con-tributing to inadequate patient ... restorative margin–tooth interfaceis a consistent finding in both research and clini-cal practice (74–81). If this margin is subgingival,the resultant increased plaque accumulation maylead to...