... oncentration that s pecifically and e ffectivelyinduced maximal inhibition of Erk1/2, p38, JNK1/2 and PtdIns 3-kinase [18,30]. The incubation was further contin-ued in the presence of S1P, anisomycin ... 30 min and then fixed, permeabilized and stained for F-actin with rhodamine-conju-gated phalloidin. Th e effects of toxin B and latrunculin B on the actin filaments wasexamined by preincubating ... expression levels of CTGF/CCN2 by a factor of 2.9 and 3.2, respectively,indicating a causal relationship between CTGF/CCN2gene induction and actin tre admilling. In addition, treat-ment of the...