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line in the sand

atlas of cyberspaceatlas of cyberspaceMartin Dodge and Rob Kitchin What does cyberspace look like?For thousands of years, people have created maps of the world around them – cave paintings, drawings in the sand, pencil sketches, lavish manuscripts, 3- pot

atlas of cyberspaceatlas of cyberspaceMartin Dodge and Rob Kitchin What does cyberspace look like?For thousands of years, people have created maps of the world around them – cave paintings, drawings in the sand, pencil sketches, lavish manuscripts, 3- pot

... ofPennsylvania). The telegraph wires linking stations into the nation wide network are shown by the thin black lines that havebeen generalized and simplified into straight -line segments. Anunderlying base ... billion users. The Atlas explores the new cartographic andvisualization techniques being employed in the mapping of cyberspace, concentrating on the following main areas:● Internet infrastructure ... is diminishing as the scale andcomplexity of infrastructure grows and information about itbecomes less open to scrutiny. It is important to interrogate the maps using the questions outlined...
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Compaction of disordered grains in the jamming limit - sand on random graphs

Compaction of disordered grains in the jamming limit - sand on random graphs

... spin-flips,where the flipping of a single spin alters the local fields acting on its neighbouringsites. The configuration of the spins on these sites may then no longer be locallystable, causing ... each spin interactswith all spins in the system, but with an interaction energy scaling as 1/√N ) willclearly not manifest this since they have in nite connectivity. More interestingly, the ... have their spins flippedbefore neighbouring spins are released.Putting all of this together, we see that in the 3-spin model, bursts in the densityfluctuations are due to cascades of spin-flips...
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Tài liệu Báo cáo khoa học: Altered expression of CD1d molecules and lipid accumulation in the human hepatoma cell line HepG2 after iron loading pptx

Tài liệu Báo cáo khoa học: Altered expression of CD1d molecules and lipid accumulation in the human hepatoma cell line HepG2 after iron loading pptx

... in iron-rich mediashowed a further increase in ROS production as deter-mined by an increase in DCFH mean fluorescenceintensity (Fig. 2B, thick line) . In addition, determin-ation of acrolein ... with iron. Thin linesrepresent background staining with mouse Igs. (B) Histogramsshow background staining with no antibody (thin lines) or with rab-bit Igs (thick lines) as first step in permeabilized ... background staining (thin lines). Cells were then acquired in a FACScali-bur and analyzed usingCELLQUEST. (A) Histograms show the expression of the molecules studied in HepG2 cells cultured in the absence(–...
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Tài liệu Báo cáo khoa học: Identification of different isoforms of eEF1A in the nuclear fraction of human T-lymphoblastic cancer cell line specifically binding to aptameric cytotoxic GT oligomers ppt

Tài liệu Báo cáo khoa học: Identification of different isoforms of eEF1A in the nuclear fraction of human T-lymphoblastic cancer cell line specifically binding to aptameric cytotoxic GT oligomers ppt

... a protein belonging to the GTP-binding elongation factor family, which promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site ofribosomes during protein biosynthesis and the capture ... sequence, increasing the number of basicresidues of lysine, arginine and histidine, could occur.However it seemed probable that the eEF1A isoformscould act as a controlling event in maintaining the viability ... quantify the amount of recoveredprotein owing to the presence of a high molar excess ofBSA remaining in the buffer. Therefore, a fixed aliquot of the protein was incubated with the indicated...
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Báo cáo khóa học: Endoplasmic reticulum-associated degradation of glycoproteins bearing Man5GlcNAc2 and Man9GlcNAc2 species in the MI8-5 CHO cell line docx

Báo cáo khóa học: Endoplasmic reticulum-associated degradation of glycoproteins bearing Man5GlcNAc2 and Man9GlcNAc2 species in the MI8-5 CHO cell line docx

... newlysynthesized glycoproteins has been demonstrated previouslyusing various mammalian cell lines. Depending on the celltype, glycoproteins bearing Man9 glycans and glycoproteinsbearing Man5 ... respectively, when the incubation was performed in the presence of20 lMkifunensine after a 20 min preincuba-tion. G1M9 indicates oligomannosides con-taining one Glc, nine Man, and two GlcNAcresidues. ... originate from the action ofUGGT. Furthermore, when the incubation was performed in the presence of 20 lMkifunensine, the formation ofMan4GlcNAc2 and Man8GlcNAc2 species was stronglyinhibited...
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Cancer Research UK’s strategy 2009–2014: Cancer Research UK’s aim is to reduce the number of deaths from cancer. Our future plans are ambitious, but they are in line with the challenge and the responsibility we face. docx

Cancer Research UK’s strategy 2009–2014: Cancer Research UK’s aim is to reduce the number of deaths from cancer. Our future plans are ambitious, but they are in line with the challenge and the responsibility we face. docx

... of relevant training in our Institutes and Centres and working in partnership where possible- Maintain our current investment in training schemes while modifying the existing portfolio where ... in training most of the medical oncologists practising in the UK. We will build on this to address the current deficit in clinician scientists working at the translational interface and in cancer ... appropriate- Continue to invest in all collaborations that help us work towards our goals- Examine the potential for broader international partnerships, including securing funding from the EU Innovative...
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Báo cáo khoa học: Protein kinase Ch activity is involved in the 2,3,7,8tetrachlorodibenzo-p-dioxin-induced signal transduction pathway leading to apoptosis in L-MAT, a human lymphoblastic T-cell line potx

Báo cáo khoa học: Protein kinase Ch activity is involved in the 2,3,7,8tetrachlorodibenzo-p-dioxin-induced signal transduction pathway leading to apoptosis in L-MAT, a human lymphoblastic T-cell line potx

... confirmed, by using the human lymphoblasticT-cell line, L-MAT, as the model, that the AhR-medi-ated pathway is in no way involved in TCDD-inducedapoptosis, [7,8]. Furthermore, neither TCDD-mediatedapoptosis ... at the N terminus, upstream of the start codon,and SalI at the C terminus, just before the stop codon ofPKCh, with pEFneo-DN PKCh being used as the template.PKCh in TCDD-induced signaling ... 915Protein kinase Ch activity is involved in the 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced signal transductionpathway leading to apoptosis in L-MAT, a humanlymphoblastic T-cell line Sohel...
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Báo cáo khoa học: Calpain 1–titin interactions concentrate calpain 1 in the Z-band edges and in the N2-line region within the skeletal myofibril doc

Báo cáo khoa học: Calpain 1–titin interactions concentrate calpain 1 in the Z-band edges and in the N2-line region within the skeletal myofibril doc

... calpain 1. We conclude that titin affords binding sites to cal-pain 1, which concentrates the protease in the regions restrained by the Z-band edge and the N1 -line as well as at the N2 -line level, ... Z -line to the M-band of the sarcomeres [23–25]. Two calpain3-binding sites, located at the C-terminal end of titin(M -line region) and at the N2 -line region (a transversedense structure at the ... N2 -line level, whereas two less-intense precipitate lines are pre-sent in the vicinity of the Z -line (Fig. 5C). In storedmuscle, the transversal fracture line is obviously adja-cent to the...
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Báo cáo khoa học: Etoposide upregulates Bax-enhancing tumour necrosis factor-related apoptosis inducing ligand-mediated apoptosis in the human hepatocellular carcinoma cell line QGY-7703 pdf

Báo cáo khoa học: Etoposide upregulates Bax-enhancing tumour necrosis factor-related apoptosis inducing ligand-mediated apoptosis in the human hepatocellular carcinoma cell line QGY-7703 pdf

... CA, USA). The cells weremaintained in RPMI-1640 containing 10% heat-inactivatedbovine serum, 1 mML-glutamine, 100 UÆml)1penicillin and100 lgÆml)1streptomycin (Life Technologies, Inc. GrandIsland, ... lesseffective than the expected effects based on tests of the compounds individually. Simply put, the point representing the dose combination lying on, below, or above the straight line represents ... TRAIL on the liver carcinoma cells QGY-7703To investigate the apoptotic function of TRAIL containing the extracellular domain (amino acids 114–281) of the human liver cancer cell line, QGY-7703...
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Báo cáo khoa học: Dual expression of mouse and rat VRL-1 in the dorsal root ganglion derived cell line F-11 and biochemical analysis of VRL-1 after heterologous expression pptx

Báo cáo khoa học: Dual expression of mouse and rat VRL-1 in the dorsal root ganglion derived cell line F-11 and biochemical analysis of VRL-1 after heterologous expression pptx

... band. The slower migrating of the two F-11PCR bands always corresponded to the rat brain control, the fastermigrating band to the N18TG2 control. In case of C the PCR productfrom rat brain appeared ... construct coding for a VRL-1-GFP fusion protein wasprepared by cloning the open reading frame of rVRL-1 fromrat brain RNA without the last codon for amino acid P761and the stop codon into pcDNA3.1/CT-GFP-TOPO ... silent gene from the neuroblastoma cell line by the DRG. They observed this phenomenon in other cellfusion experiments.Depending on growth conditions these fusion cells altertheir morphology...
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