... HolfordUniversity of AucklandDepartment of Pharmacology and ClinicalPharmacologySchool of MedicineGrafton, AucklandNew ZealandLawrence J. Lesko Food and Drug Administration Of ce of Clinical ... transport, and biotechnology and in our understanding of thepathways of drug metabolism, mechanisms of enzymeinduction, and adverse drug reactions have warrantedthe preparation of this new edition. We ... thecurrent edition of the course are available on the Internetat: http://www.cc.nih.gov/ccc /principles Preface to the Second Edition Five years have passed since the first edition of Principles of Clinical...