... School of Medicine, UCLA, Los Angeles, CA, USAIntroductionApolipoprotein E (ApoE) is a major protein of thelipid and lipoprotein transport system mainlyinvolved in the metabolism of dietary ... the glucose tolerance and insulin sensitivity of theApoE) ⁄ )· Ay⁄ +mice, and triggered obesity, indicat-ing that circulating ApoE is involved in increasedadiposity and obesity-related metabolic ... phenotype and insulin and glucose levelsbecame stronger with increasing body mass index[60,61]. These findings again raise the interesting possi-bility that, although hyperplastic types of obesity...