Báo cáo Y học: Inhibition of SERCA Ca2+ pumps by 2-aminoethoxydiphenyl borate (2-APB) 2-APB reduces both Ca2+ binding and phosphoryl transfer from ATP, by interfering with the pathway leading to the Ca2+-binding sites ppt

Báo cáo Y học: Inhibition of SERCA Ca2+ pumps by 2-aminoethoxydiphenyl borate (2-APB) 2-APB reduces both Ca2+ binding and phosphoryl transfer from ATP, by interfering with the pathway leading to the Ca2+-binding sites ppt

Báo cáo Y học: Inhibition of SERCA Ca2+ pumps by 2-aminoethoxydiphenyl borate (2-APB) 2-APB reduces both Ca2+ binding and phosphoryl transfer from ATP, by interfering with the pathway leading to the Ca2+-binding sites ppt

... inhibition of SERCA (Eur. J. Biochem. 269) 3687 Inhibition of SERCA Ca 2+ pumps by 2-aminoethoxydiphenyl borate (2-APB) 2-APB reduces both Ca 2+ binding and phosphoryl transfer from ATP, by interfering with ... data to show that 2-APB can inhibit the SERCA Ca 2+ pumps by reducing both the affinity of Ca 2+ binding and phosph...
Ngày tải lên : 31/03/2014, 23:20
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Báo cáo Y học: Inhibition of the SERCA Ca21 pumps by curcumin Curcumin putatively stabilizes the interaction between the nucleotide-binding and phosphorylation domains in the absence of ATP pot

Báo cáo Y học: Inhibition of the SERCA Ca21 pumps by curcumin Curcumin putatively stabilizes the interaction between the nucleotide-binding and phosphorylation domains in the absence of ATP pot

... that the nucleotide -binding domain is highly mobile in the presence of Ca 2þ and can come into close contact with the phosphorylation site by simple thermal fluctuation [15]. From this type of analysis ... the absence and presence of curcumin, and controls to estimate nonspecific binding of ATP to the filter were performed as described previously [16]. Phosp...
Ngày tải lên : 08/03/2014, 23:20
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Tài liệu Báo cáo Y học: Inhibition of the MEK/ERK signaling pathway by the novel antimetastatic agent NAMI-A down regulates c-myc gene expression and endothelial cell proliferation ppt

Tài liệu Báo cáo Y học: Inhibition of the MEK/ERK signaling pathway by the novel antimetastatic agent NAMI-A down regulates c-myc gene expression and endothelial cell proliferation ppt

... hypo- thesis is further confirmed by the observation that, differ- ently from the effect of serum, the stimulatory effect of PMA on ERK1/2 activity could also be totally abolished by NAMI-A. Within ... to the phosphorylation of ERK1/2 isoenzymes (Fig. 2B). To verify the involvement of a PKC-dependent pathway in both serum- and PMA-generated ERK1/2 phosphoryla-...
Ngày tải lên : 21/02/2014, 01:21
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Tài liệu Báo cáo Y học: Inhibition of nuclear pre-mRNA splicing by antibiotics in vitro pot

Tài liệu Báo cáo Y học: Inhibition of nuclear pre-mRNA splicing by antibiotics in vitro pot

... 2). The sixfold stron ger splicing inhibition by Cl-tetracycline may be explained by the a dditional s ize and hydrophobicity introduced by the substitution, as is often the case in ribozyme inhibition ... aminoglycoside, kanamycin, the a minocyclitol glycoside, streptomycin, t he penicillins, ampicillin and penicillin G, the aminocyclitol, spectinomycin, tetracyclin...
Ngày tải lên : 21/02/2014, 15:20
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Báo cáo Y học: Inhibition of hyaluronan synthesis in Streptococcus equi FM100 by 4-methylumbelliferone doc

Báo cáo Y học: Inhibition of hyaluronan synthesis in Streptococcus equi FM100 by 4-methylumbelliferone doc

... contribute to their pathogenicity by allowing them to escape from the immune systems of their hosts. The HA synthesized by Streptococci is not chemically or structurally distinguishable from that synthesized ... mechanism of inhibition of HA synthesis by MU is probably due to an alteration of the lipid environment of the Streptococcal membranes. MATERIALS...
Ngày tải lên : 08/03/2014, 09:20
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  • 541
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Báo cáo Y học: Inhibition of glycosyl-phosphatidylinositol biosynthesis in Plasmodium falciparum by C-2 substituted mannose analogues pot

Báo cáo Y học: Inhibition of glycosyl-phosphatidylinositol biosynthesis in Plasmodium falciparum by C-2 substituted mannose analogues pot

... understanding of the biosynthesis pathway and function of GPtdIns came from the use of specific inhibitors of the GPtdIns biosynthesis. A recently established fungi metabolite (YW3548) was shown to ... 2-deoxy-2-fluoro- D-glucose and 2-amino-2-deoxy-D-mannose) have been used to study glycosylphosphatidylinositol (GPtdIns) biosynthesis and GPtdIns protein anchoring in...
Ngày tải lên : 31/03/2014, 23:20
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Báo cáo y học: "Extension of the PNA world by functionalized PNA monomers eligible candidates for inverse Diels Alder Click Chemistyr"

Báo cáo y học: "Extension of the PNA world by functionalized PNA monomers eligible candidates for inverse Diels Alder Click Chemistyr"

... night and the reaction’s completeness was checked by thin layer chromatography. The reaction prod- uct was inspissated by the rotary evaporator and consecu- tively und covered with ether. The ... Synthesis of the PNA building block backbone In the next step, the synthesis of the PNA back- bone monomer using the fluorenylmethoxycarbonyl (Fmoc) protection occ...
Ngày tải lên : 26/10/2012, 08:57
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Báo cáo Y học: Characterization of the exopolysaccharide produced by Streptococcus thermophilus 8S containing an open chain nononic acid doc

Báo cáo Y học: Characterization of the exopolysaccharide produced by Streptococcus thermophilus 8S containing an open chain nononic acid doc

... studies. ACKNOWLEDGEMENTS This study was supported by the PBTS Research Program with financial aid from the Ministry of Economic Affairs and by the Integral Structure Plan for the Northern Netherlands from the Dutch Develop- ment ... composition of the EPS produced by S. thermophilus 8S, the genetics and biochemistry of the EPS biosynthesis as well as the...
Ngày tải lên : 08/03/2014, 09:20
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  • 537
  • 1
Báo cáo khoa học: Inhibition of Drosophila melanogaster acetylcholinesterase by high concentrations of substrate potx

Báo cáo khoa học: Inhibition of Drosophila melanogaster acetylcholinesterase by high concentrations of substrate potx

... used instead of the substrate to avoid decarbamoylation due to transcarb- amoylation by the choline, generated from the substrate hydrolyzed by the noncarbamoylated fraction of the enzyme. Figure ... simultaneously to the free and the acetylated enzyme as shown by structural studies [30] and (b) the occupation of the anionic subsite at the bottom o...
Ngày tải lên : 16/03/2014, 16:20
  • 8
  • 360
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Báo cáo khoa học: Inhibition of a-synuclein fibrillization by dopamine analogs via reaction with the amino groups of a-synuclein Implication for dopaminergic neurodegeneration pot

Báo cáo khoa học: Inhibition of a-synuclein fibrillization by dopamine analogs via reaction with the amino groups of a-synuclein Implication for dopaminergic neurodegeneration pot

... also retains the cytotoxicity, supporting the hypothesis that the cyto- toxicity primarily arises from the reaction adduct or the a-Syn oligomers rather than from free DA or the a-Syn fibrils. Although ... reactions of a-Syn with quinone and DA. (A) Overlay of the 1 H- 15 N HSQC spectra of a-Syn (black) and the reaction product of a-Syn and Q (red). (B) Over...
Ngày tải lên : 23/03/2014, 15:20
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