Báo cáo Y học: LRP130, a protein containing nine pentatricopeptide repeat motifs, interacts with a single-stranded cytosine-rich sequence of mouse hypervariable minisatellite Pc-1 docx
Báo cáo Y học: LRP130, a protein containing nine pentatricopeptide repeat motifs, interacts with a single-stranded cytosine-rich sequence of mouse hypervariable minisatellite Pc-1 docx
... LRP130, a protein containing nine pentatricopeptide repeat motifs, interacts with a single-stranded cytosine-rich sequence of mouse hypervariable minisatellite Pc-1 Naoto Tsuchiya, Hirokazu ... Fukuda, Takashi Sugimura, Minako Nagao and Hitoshi NakagamaBiochemistry Division, National Cancer Center Research Institute, Chuo-ku, Tokyo, JapanRecently, we have identified and purified minisatellite ... containing 2 lg of poly (A) +RNA perlane were analyzed by hybridization with the 5¢ region of 32P-labeledmLRP130 cDNA as described in Materials and methods. Arrowheadsindicate a band of 4.7-kb...
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Báo cáo y học: " Facilitators and obstacles in pre-hospital medical response to earthquakes: a qualitative study"
... earthquake in Taiwan [16,39] and the Gujaratearthquake in India [44].As demonstrated, the army plays an important part inthe early response to earthquakes. The army can beused in all parts of ... weretriaged, albeit in a limited fashion, without standardiza-tion or overall coordination and with a delayed start.They divided the airport waiting rooms into a few sepa-rate areas. They evaluated ... the airtransport organization, to provide the evacuation by air.In addition they carried managers, medical teams andequipment to the earthquake area. A participant said “The air force managed...
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Báo cáo y học: "Intrathecal siRNA against Toll-like receptor 4 reduces nociception in a rat model of neuropathic pain"
... hyperalgesia The paw withdrawal latency (PWL) to radiant heat and paw withdrawal threshold (PWT) were used to evaluate thermal hyperalgesia and mechanical al-lodynia respectively as previously ... UACGAC-3”). SiRNAs targeting the cDNA sequence of rat TLR4 (GenBank accession NM_019178) were: 5’-CUACCAACAGAGAGGAUAU-3” (siRNA1), 5’-GUCUCAGAUAUCUAGAUCU-3’ (siRNA2), 5’-GAGCCGGAAAGUUAUUGUG-3’ ... transfection reagent (Neuromics, Edina, MN, USA) was administered intrathecally once daily for 7 days, starting from 1 day before CCI surgery. Evaluation of tactile allodynia and thermal hyperalgesia...
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Báo cáo Y học: Probing intermolecular protein–protein interactions in the calcium-sensing receptor homodimer using bioluminescence resonance energy transfer (BRET) potx
... PharmaBiotec Research Centre, Department of Medicinal Chemistry, The Royal Danish School of Pharmacy,Copenhagen, Denmark;2Laboratory of Molecular Cardiology, Copenhagen University Hospital, ... displayed a potency atAT1aD359-GFP2not significantly different from that atFig. 4. Immunofluorescence analysis of c-myc- and HA-tagged CaRs. Visualization of cell surface expression of tsA cells ... 5079HA-tagged GABAB1receptors, when these were cotrans-fected with WT GABAB2(data not shown).The c-myc-CaR/HA-CaR, c-myc-CaRD1036-Rluc/HA-CaRD1036-GFP2and c-myc-CaRD886-Rluc/HA-CaRD886-GFP2transfected...
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Báo cáo Y học: SF2/ASF protein inhibits camptothecin-induced DNA cleavage by human topoisomerase I potx
... assay asÔphosphorylated SF2/ASFÕ.The amount of htopo I and SF2/ASF was quantified bydensitometric scanning of SDS-polyacrylamide gels usingBSA as a standard.DNA cleavage assayRoutinely, ... Relaxation activity was calculated fromdecrease of the amount of supercoiled DNA. One unitrelaxed 50% of the substrate DNA after 30 min at 30 °C.Kinase assayHtopo I kinase activity was measured ... Warsaw University, Warsaw, Poland A splicing factor SF2/ASF is a natural substrate for thekinase activity of human topoisomerase I. This study dem-onstrates that SF2/ASF inhibits DNA cleavage...
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Báo cáo Y học: Substrate selectivity and sensitivity to inhibition by FK506 and cyclosporin A of calcineurin heterodimers composed of the a or b catalytic subunit potx
... CaNa and CaNb. These findings alsoindicate that FKBP12/FK506 is a more potent inhibitor of both CaNa and CaNb than CyPA/CsA.Activation of CaNa and CaNb phosphatase activityby FKBP12/FK506 toward ... isoform-specific antibodies confirm that CnAa andCnAb proteins are expressed by the appropriate recombin-ant CnAa and CnAb baculoviruses (Fig. 1B,C).Kinetic assays of CaNa and CaNb phosphatase ... catalytic site[20]. The amino-acid sequences of the CnAa and CnAbcatalytic domains are 90% identical, and the autoinhibitorydomain amino-acid sequences are 89% identical, suggestingthat CaN...
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Báo cáo Y học: Mitogen-activated protein kinase kinase negatively modulates ciliary neurotrophic factor-activated choline acetyltransferase gene expression pdf
... units.Statistical analysisOne- or two-way analysis of variance, as appropriate, andTukey's test were performed with the help of SYSTATstatistical software (SPSS Inc., Chicago, IL, USA) usingMacintosh ... acetylcholine (ACh)from choline and acetyl coenzyme A is catalyzed by theenzyme choline acetyltransferase (ChAT, acetyl-CoA:cho-line O-acetylotransfe rase, EC 2.3.1.6) [1]. Following syn-thesis, ACh ... possiblyas a p art of a feedback mechanism.Keywords: acetylcholine; choline acetyltransferase; MAPkinase; c iliary neurotrophic factor; Stat3.Biosynthesis o f the neurotransmitter acetylcholine...
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Báo cáo y học: "Trace Elements, Heavy Metals and Vitamin Levels in Patients with Coronary Artery Diseas"
... Heavy Metals and Vitamin Levels in Patients with Coronary Artery Disease Aysegul Cebi1, Yuksel Kaya2, Hasan Gungor3, Halit Demir4, Ibrahim Hakki Yoruk4, Nihat Soylemez2, Yilmaz ... Hospital, Department of Cardiology, Mus, Turkey 4. Yuzuncu Yil University Faculty of Science, Department of Chemistry, Van, Turkey 5. Yuzuncu Yil University, Faculty of Medicine, Department of Cardiology, ... patients hav-ing angiographically demonstrated CAD and 20 pa-tients having normal coronary arteries attending car-diology clinic at Yuzuncu Yil University Hospital. The study was approved by the...
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Báo cáo y học: "Skeletal muscle sodium glucose co-transporters in older adults with type 2 diabetes undergoing resistance training"
... analysis was adjusted for age, gender and years with diabetes. Secondary Analysis of Predictors of the Change in Main Outcomes Baseline univariate correlation analyses showed that hSGLT3 transcript ... log-transformed variables for analyses. Data are shown as mean and standard deviation (SD) or median for non-normally distributed variables. Baseline comparisons were assessed by independent sample ... study outcomes, analysis of covariance of the absolute change (week 16 – week 0) in each outcome variable was carried out adjusted for age, gender and years with diabetes when appropriate....
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Báo cáo Y học: Soluble guanylate cyclase is allosterically inhibited by direct interaction with 2-substituted adenine nucleotides doc
... receptor-coupled regulation of adenylate cyclaseand accumulation of [cAMP]i. In addition, the catalyticdomains of adenylate cyclases are allosterically regulated byadenine nucleotides. Thus, adenine nucleotides, ... composed of a and b subunits andeach monomer contains a heme binding domain, a dimeri-zation domain, and a catalytic domain [1,6]. The primarystructure of the catalytic domains of sGC and pGC arehomologous, ... allosterically inhibit basal and ligand-stimulatedsGC. They support the suggestion that allosteric inhibitionby adenine nucleotides is a general characteristic of thefamily of guanylate cyclases....
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