Báo cáo Y học: When the embryonic genome flexes its muscles Chromatin and myogenic transcription regulation ppt
Báo cáo Y học: When the embryonic genome flexes its muscles Chromatin and myogenic transcription regulation ppt
... MINIREVIEW When the embryonic genome flexes its muscles Chromatin and myogenic transcription regulation Ralph A. W. Rupp1, Nishant Singhal1 and Gert Jan C. Veenstra21Adolf-Butenandt-Institut, ... forexample for the lysozyme gene in myeloid cells [67], and for the b-globin gene in erythrocytes [68]. Priming by SWI/SNFcomplexes may even apply to the myogenic determinationgenes themselves. ... ofMyoD. This modification increases both MyoD’s DNAbinding activity [42] and its affinity for p300/CBP [43].Preventing acetylation of MyoD by mutating these lysinesimpaired the ability of MyoD...
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Báo cáo Y học: Monitoring the structural consequences of Phe12 fi D-Phe and Leu15 fi Aib substitution in human/rat corticotropin releasing hormone Implications for design of CRH antagonists pdf
... b-endorphin and otherproopiomelanocortin products of the anterior pituitarygland. CRH is considered to be the key hormone in the control of the hypothalamic–pituitary–adrenal axis func-tion and is ... 3A shows the family of 40 structures and Table 1 contains a summary of statistical data indica-ting the quality of the 40 models and the average energy-minimized structure. The polypeptide ... preparation The CRH analogue was synthesized using Fmoc/tBuchemistry by solid-phase peptide synthesis and was purified and characterized via reversed phase HPLC and ESI-MS[14]. The CRH analogue...
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Báo cáo Y học: Two different E2F6 proteins generated by alternative splicing and internal translation initiation ppt
... Exon2-mut-luc), and compared its activity to the activity of Exon2-luc in transient transfectionassays. The mutation led to complete loss of activity in theseassays, indicating that the integrity of the ... asynchronously growing cells (asynchr.)was also analyzed. The percentage of cells in the G0/G1, S, and G2/Mphases of the cell cycle at each time point was determined by FACSanalysis and is shown at the ... Biology and Tumor Research(IMT), Philipps-University Marburg, GermanyE2F transcription factors play an important role in the regulation of cell cycle progression. E2F6, the most recentlyidentified...
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Báo cáo y học: "Demonstrating the benefit of medical emergency teams (MET) proves more difficult than anticipated"
... maintained by use of regular reminders until the first day of the study period. The staff designated to form the MET varied between participating centers because of local circumstances. The study protocol ... that the MET to be at least the equivalent of the pre-existing cardiac arrest team and consist of at least one doctor and a nurse from the emergency department or ICU. A 6-month study period ... emergency team (3.1 vs 8.7 per 1000 admissions, p=0.0001). The MET was called to 30% of patients who fulfilled the calling criteria and who were subsequently admitted to the ICU. During the study,...
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Báo cáo y học: " Introducing the Critical Care Forum’s ongoing review of medical statistics"
... but rather a starting point to inform readers and stimulatemore thought and investigation as to the most appropriate statistical methods to use and the theory and assumptions behind them.Keywords ... the series include: standard errors and confidenceintervals; hypothesis testing and errors; power calculations;measures of disease; parametric and non-parametric tests;simple regression; and ... analysis of survival data. Ideally the series will evolve to meet the needs of Critical Care readers, and you are encouraged to suggest additional topics that youwould like to see covered in the...
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Tài liệu Báo cáo Y học: Short peptides are not reliable models of thermodynamic and kinetic properties of the N-terminal metal binding site in serum albumin doc
... b(HnL), j and n ¼ 2, except for DAHKam, where j ¼ 1 and n ¼ 3.bNi(II) data from ref [11].c[31].d[36].eglycylglycylhistamine, [9].fa-hydroxymetylseryl-a-hydroxymetylserylhistidinamide; ... Bal1,21Faculty of Chemistry, University of Wroclaw, Poland;2Institute of Biochemistry and Biophysics, Polish Academy of Sciences,Warsaw, PolandA comparative study of thermodynamic and kinetic ... pooled and lyophilized to yield with solid ofpurity exceeding 99% as assessed by HPLC analysis of the final m aterials. I dentity and purity of peptide was confirmedby mass spectrometry, utilizing...
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Tài liệu Báo cáo Y học: Exploring the role of a glycine cluster in cold adaptation of an alkaline phosphatase pdf
... resulted in an enzyme with slightly lower stability.On the other hand, in the double mutant G261A /Y2 69A the additional replacement of Tyr269 by Ala restores the stability of the protein producing ... of the psychrophilicalkaline phosphatase was built [21] on the basis of the homology to the E.colienzyme the structure of which isknown [24]. For display of the model and for design and analysis ... focused to the vicinity of the active site of the psychrophilic alkaline phosphatase from the AntarcticTable 1. Enzymatic and thermodynamic parameters of the psychrophilic alkaline phosphatase and...
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Tài liệu Báo cáo Y học: Dissecting the effect of trifluoroethanol on ribonuclease A Subtle structural changes detected by nonspecific proteases ppt
... detected by proteolysis(see below), we investigated RNase A in the absence and presence of 20% trifluoroethanol by NOESY and TOCSYNMR spectroscopy. However, due to the high pH value(8.0) and the ... P. Bayer,Max-Planck Institute of Molecular Physiology, Dortmund, Germany,for performing NMR spectroscopy experiments. The support for JensKo¨ditz by the Land Sachsen-Anhalt and by the Max-Buchner-Forschungsstiftung, ... temperatures, theydestroy the tertiary structure of proteins which results in the loss of enzymatic activity. Regarding the secondary struc-ture of proteins, however, organic solvents generally differfrom...
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Báo cáo Y học: Properties of group I allergens from grass pollen and their relation to cathepsin B, a member of the C1 family of cysteine proteinases pdf
... prosequences from the recombinant allergen is facilitated by its N-glycosylation and that the truncated, activated allergen shows proteolyticactivity, resulting in very low stability of the protein. ... conserved cysteine residues and other essential amino acids are numbered.Areas of high similarity exist around Cys69 and Cys72 and around Trp186, Trp193 and Trp197. The positions of Cys41, 57, 69 and ... The glycosylated allergen Phl p 1 N shows a muchmore pronounced proteolytic activity than the nonglycosylated aller-gen. (C) Effect of enzymatic deglycosylation on rPhl p 1 N activity inzymograms....
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Báo cáo Y học: Trehalose-phosphate synthase of Mycobacterium tuberculosis Cloning, expression and properties of the recombinant enzyme pdf
... Sasaki, N., Okazaki, Y. , Muramatsu, M. &Hayashizaki, Y. (1988) Thermostabilization and thermoactiva-tion of thermolabile enzymes by trehalose and its application for the synthesis of full-length ... in the synthesis of trehalose-P and/ or free trehaloseappear to have an important and probably essentialfunction in the physiology of many organisms. The most widely demonstrated pathway for the ... of the recombinantTPS.Afteranincubationof15min,onesetofincubationmixtures was assayed by the anthrone colorimetric method and the other set was assayed by the coupled enzyme assay where the...
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