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Báo cáo Y học: The amyloid precursor protein interacts with neutral lipids Liposomes and monolayer studies pdf

Báo cáo Y học: The amyloid precursor protein interacts with neutral lipids Liposomes and monolayer studies pdf

Báo cáo Y học: The amyloid precursor protein interacts with neutral lipids Liposomes and monolayer studies pdf

... microdomains.Keywords: amyloid precursor protein; liposomes; monolayer; phospholipids; protein lipid interactions.Limited proteolysis of the amyloid precursor protein (APP)generates the amyloid- b -protein (Ab), ... The amyloid precursor protein interacts with neutral lipids Liposomes and monolayer studies Raghda Lahdo1, Ste´phane Coillet-Matillon1, Jean-Paul Chauvet2 and Laurence de ... Therefore, alteration of the charge of the protein could be induced at the vicinity of the monolayer. Adifference in the orientation of the protein moiety during the insertion process into the...
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Tài liệu Báo cáo Y học: The Ikaros family protein Eos associates with C-terminal-binding protein corepressors pptx

Tài liệu Báo cáo Y học: The Ikaros family protein Eos associates with C-terminal-binding protein corepressors pptx

... early stages of differentiation and to the lymphoid compartment in the adult [2,3]. The Ikaros genecodes for a protein with six zinc fingers that comply with the Kru¨ppel C2-H2 consensus. The ... The Ikaros family protein Eos associates with C-terminal-binding protein corepressorsJose´Perdomo and Merlin CrossleyDepartment of Biochemistry, G08, University of Sydney, NSW, AustraliaEos ... interfere with their functions. Aiolos–/–mice show expanded B cell populations and autoimmunity,but are normal in their thymic and splenic T cell develop-ment [13], a phenotype consistent with the...
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Báo cáo Y học: The S100A8/A9 protein as a partner for the cytosolic factors of NADPH oxidase activation in neutrophils doc

Báo cáo Y học: The S100A8/A9 protein as a partner for the cytosolic factors of NADPH oxidase activation in neutrophils doc

... neutrophils the S100A8/A9 protein was evenly distributed within the cytoplasm and that after activation of the cells by phorbol ester, itconcentrated under the plasma membrane, together with the cytosolic ... fol-lowed by isoelectric focusing. The S100A8/A9 heterodimeric protein comigrated with the cytosolic phox proteins, and more particularly with p67phox and Rac2, whereas the isolated S100A8 protein ... of the theoretical maximal activity. When S100A8/A9 was presenttogether with the phox cytosolic proteins, the reciprocal plotsbecome more linear. Linearity increased with the increase inthe...
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Báo cáo khoa học: Anti-amyloid precursor protein immunoglobulins inhibit amyloid-b production by steric hindrance ppt

Báo cáo khoa học: Anti-amyloid precursor protein immunoglobulins inhibit amyloid-b production by steric hindrance ppt

... that is cleaved from amyloid precursor protein (APP) [5]. APP can beprocessed by one of two proteolytic pathways. The KeywordsAlzheimer’s disease; amyloid precursor protein; amyloid- b; monoclonal ... (2004) Passive amyloid immuno-therapy clears amyloid and transiently activates micro-glia in a transgenic mouse model of amyloid deposition.J Neurosci 24, 6144–6151.36 Arbel M, Yacoby I & ... sAPPa from the non-amyloidogenic a-secretase pathway and intracellular APP were not affectedby either antibody nor were there any effects on cell viability. 2B3 exhib-ited a higher affinity for...
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Báo cáo y học:

Báo cáo y học: "Parvovirus B19 Nonstructural Protein-Induced Damage of Cellular DNA and Resultant Apoptosis"

... pathway was investigated by studying the activity of Poly(ADP-ribose)Polymerase (PARP), the protein which detects nicks in DNA and activates the repair process. Both the nick repair and ATR/ATM-mediated ... hepatocytes. We hypothesized that the cyto-toxicity of NS1 in such cells results from chromosomal DNA damage caused by the DNA-nicking and DNA-attaching activities of NS1. Upon testing this hypothesis, ... p a i r pathway initiated by poly(ADPribose)polymerase and the DNA repair pathways initiated by ATM/ATR are necessary for efficient apoptosis resulting from NS1 expression. Key words: Parvovirus...
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Báo cáo y học:

Báo cáo y học: "The Syndrome of Frontonasal Dysplasia, Callosal Agenesis, Basal Encephalocele, and Eye Anomalies – Phenotypic and Aetiologica"

... from 5 months to 15 years. Parental age was within the population average. Family history was obtained by personal interview. Pregnancy history and delivery were unremarkable. There was no reference ... a syndrome belonging to frontonasal dysplasia spectrum. The ten cases confirm a distinct clinical entity and help to define the phenotype more precisely than previously. Up to now etiology ... variable. The former ranges from mild hypertelorism with a median upper lip notch to median cleft involving the lip and the nose, and the later includes findings such as ptosis, orbital asymmetry,...
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Báo cáo Y học: Recombinant pronapin precursor produced in Pichia pastoris displays structural and immunologic equivalent properties to its mature product isolated from rapeseed pptx

Báo cáo Y học: Recombinant pronapin precursor produced in Pichia pastoris displays structural and immunologic equivalent properties to its mature product isolated from rapeseed pptx

... short length of the IPF and would agree with the relevant role attributed tothis peptide in the correct folding of the protein. The strategy of synthesizing precursors of proteins by recom-binant ... [5,19,31]. In contrast, LMW-napins aremildly polymorphic, but they are barely produced in the seeds, purified with a very low yield and mostly contamin-ated with the HMW-napins. Recombinant productionrepresents ... cloning strategy was based on the PCR method using the synthesized cDNA as template and both sense and antisense primers (NIB-1 and NIB-2) and the TaqGoldDNA polymerase (Applied Biosystems PE) dissolved...
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Báo cáo y học:

Báo cáo y học: "Line bisection performance in patients with generalized anxiety disorder and treatment-resistant depressionLine bisection performance in patients with generalized anxiety disorder and treatment-resistant depression"

... another scale of dissi-mulation (infrequency or lie) were randomly inserted into the test body. Any score above 3 on the infre-quency scale suggests either inattention to the content of the ... bisected slightly more frequently to the left of the true center, whereas healthy subjects bisected slightly more frequently to the right. The difference between the healthy subjects Int. ... depression, and both patients scored lower on the Sociability trait. Patients with GAD also bisected lines significantly leftward compared to the healthy subjects. The Fre-quency of the bisection...
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Tài liệu Báo cáo khoa học:

Tài liệu Báo cáo khoa học: "The grapho-phonological system of written French: Statistical analysis and empirical validation" pdf

... both the immediate naming and the delayed naming task. By-subjects and by-items (Ft and F2, respectively) analyses of variance were performed with grapheme frequency and grapheme entropy as within-subject ... standard deviations above and below the mean by subject and condition were replaced by the corresponding mean. Average reaction times and error rates were then computed by subjects and by ... and the other had a low averaged grapheme frequency, with entropy kept constant. Similarly, the entropy list included 32 pairs of pseudowords with contrasting average values of entropy and...
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Báo cáo khoa học: The duality of LysU, a catalyst for both Ap4A and Ap3A formation pdf

Báo cáo khoa học: The duality of LysU, a catalyst for both Ap4A and Ap3A formation pdf

... ATP (25 mm ), and the other with ATP (0.1–20 mm) and fixed l-lysine (0.5 mm).For each assay, the LysU reaction mixture with addedl-lysine and ATP was transferred to the cuvette and equilibrated ... (1995) The crystal struc-ture of the lysyl-tRNA synthetase (LysU) from Escheri-chia coli. Structure 3, 163–176.3 Ito K, Oshima T, Mizuno T & Nakamura Y (1994)Regulation of lysyl-tRNA synthetase ... spectroscopy and thin-layer chromatography.Eur J Biochem 136, 469–479.18 Hughes SJ, Tanner JA, Hindley AD, Miller AD & GouldIR (2003) Functional asymmetry in the lysyl-tRNAsynthetase explored by...
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