... for
extracellular ligands in the pericellular environment
[15] (Fig. 2). The remaining portion of the membrane-
bound receptor loses its ability to bind ligands, and
can be further processed by the presenilin ... hydrophobic
environment (mainly between Leu403 and Val404) of
the phospholipid bilayer of the membrane [17]. In
turn, there is decreased plasma membrane targeti...
... sets L
p
and L
n
of
known Positive and Negative terms, respectively,
and expands them into the two final training sets
T r
p
⊃ L
p
and T r
n
⊃ L
n
by adding them new sets
of terms U
p
and U
n
found ... orien-
tation) is given by the sum of the weights of its
semantic association with the seed positive terms
minus the sum of the weights of its semantic as-
soci...
... entry of fatty acid into mitochon-
dria. Thus, the steady-state level of malonyl-CoA in
these tissues is determined by the relative activities of
ACC and malonyl-CoA decarboxylase.
Role of the ... ghrelin
and adiponectin alter hypothalamic AMPK and malo-
nyl-CoA levels [13,23,28,30–33]. The genetic evidence
for the role of AMPK in the hypothalamus is less clear
bec...
... molecule takes the position of
the adenine ring of ATP. The carbon and
oxygen atoms of pantoate are shown in
yellow and red, respectively. The carbon
and oxygen atoms of ATP are shown in red,
the nitrogen ... between
the O2 atom of pantoate and the Nf atom of the side
chain of Lys39. However, there are a large number of
water-mediated networked interact...
... performed and
the P-values are displayed, as calculated using the Student’s t-test. The mean and standard deviations of absolute numbers of the observed
colonies are indicated. (C) Number of colonies ... were lysed and dilutions plated and cultured for 2 days at
27 °C. The number of colonies for OTUB1 and the OTUB1 mutants were counted and presented relative to...
... 158(21)
and 296(154) [14–17]. The high specific activity of these
FVIIa variants is presumably linked to a more stable
burial of the N-terminus of the protease domain in the
activation pocket of the ... included in the pub-
lished alanine scanning mutagenesis study of FVIIa
[13], and investigated the effects of the mutation on
the enzymatic maturation of FVI...
... number of these modifications is low, the density of
modifications is much the same as in the rest of the lin-
ker histones. It is the shortness of the N-terminal tails
Table 1. Alignment of chicken, ... studies [14–16] suggest that the linker
histone is close to the dyad axis of the core particle at
the entry and exit of the DNA. Similarly, the geometry...
... presenting the pulse of Src activity in the plane
of the inactive and active fractions, s
i
and s
1
. If the
duration of the stimulus exceeds the critical value, the
trajectory in the (s
i
, ... conformation, the
SH2 domain binds to pY
i
on the C-terminal tail, and
the Src homology 3 (SH3) domain binds to the linker
between the SH2 and kinase domains at...
... except WhiB2, the amino acid imme-
diately after the C-terminal cysteine of the CXXC
motif is proline (Fig. S6). In WhiB2 the absence of
proline and therefore of the kink might not allow the
protein ... conditions [15]. The rate of dis-
integration was directly correlated with the duration
and strength of the oxidizing environment. Similarly,
in this study, th...
... resulted in 55% and 51%
loss of the initial activities of BHLmL2 and BHAb,
respectively. These results strongly suggest that Ser is
involved in the catalytic activity of BHLmL2 and
BHAb and are consistent ... 97% inhibition of
BHLmL2 and BHAb, respectively.
The influence of pH on the activities of the BH
enzymes was investigated in the pH range 6–11. The
pH...