... protein kinase; MMP, matrix metalloproteinase; NF-jB, nuclear factor kappa B; PI3K,phosphatidylinositol 3-kinase; PKC, protein kinase C; Pyk2, proline-rich tyrosine kinase 2; RTK, receptor tyrosine ... (1993) High affinity bindingand direct antiproliferative effects of luteinizing hor-mone-releasing hormone analogs in human endome-trial cancer cell lines. J Clin Endocrinol Metab 77,1458–1464.31 ... mitogen-activatedprotein kinase ⁄ extracellular signal-regulated kinasecascade in gonadotropin-releasing hormone-inducedgrowth inhibition of a human ovarian cancer cell line.Cancer Res 59, 5133–5142.77...