Báo cáo khoa học: Role of the N- and C-terminal regions of the PufX protein in the structural organization of the photosynthetic core complex of Rhodobacter sphaeroides pptx
Tài liệu Báo cáo khoa học: Role of K22 and R120 in the covalent binding of the antibiotic fosfomycin and the substrate-induced conformational change in UDP-N-acetylglucosamine enol pyruvyl transferase docx
... with the K22V and K22E mutantproteins. This was interpreted as a lack of fosfomycinbinding to these mutant proteins [12]. Binding of fosfomycinto either wild-type MurA or the K22 mutant proteins ... of R120 by lysine reduces the probability of forming the fully closed form of the protein. The results obtained with the K22V/R120K doublemutant protein point toward a central role of arginine ... Takentogether, our combined calorimetric and protein chemicalapproach leads to a more detailed understanding of the role of K22 and R120 with respect to fosfomycin binding as wellas the ligand-induced...
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Báo cáo khoa học: Role of the hinge peptide and the intersubunit interface in the swapping of N-termini in dimeric bovine seminal RNase pptx
... Role of the hinge peptide and the intersubunit interface in the swapping of N-termini in dimeric bovine seminal RNaseCarmine Ercole1, Francesca Avitabile1, Pompea Del Vecchio1, Orlando ... result alsoprovides indirect evidence of correct pairing of the inter-chain disulfide bridges in the recombinant sample [11]. The kinetics of the N-terminal arms swapping in the P19A-BS-RNase ... stability of the monomer. Overall,these results suggest that the structural determinants thatcontrol the exchange of N-terminal arms in BS-RNase maynot be located within the hinge peptide, and point...
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Báo cáo khoa học: Mycobacterium tuberculosis ClpC1 Characterization and role of the N-terminal domain in its function ppt
... additional N-domain, homologousto the N-domains of ClpA or ClpB, and a linkerdomain homologous to, but half the size of, the linker domain of ClpB [19]. The N-terminal regioncontains two 32-amino ... shockproteins ClpP1, ClpC1, ClpX and ClpC2 have beenannotated. Bearing in mind the importance of the Clpfamily of proteins in survival and virulence, it is of interest to understand the mode of ... of action of theseproteins in M. tuberculosis. In this study, we functionally characterized the ClpC1 protein of M. tuberculosis, and investigated the role of its N-terminal repeats in its activity....
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Báo cáo khoa học: Role of the N- and C-terminal regions of the PufX protein in the structural organization of the photosynthetic core complex of Rhodobacter sphaeroides pptx
... between the RC and the cytbc1 in the presence of mutated PufX protein The role of the PufX protein in facilitating the ubiquinone/ubiquinol exchange between the QBsite of the RC and the ubiquinone ... Role of the N- and C-terminal regions of the PufX protein in the structural organization of the photosynthetic core complex of Rhodobacter sphaeroides Francesco Francia1,2, ... important role in the structure of the core complex [12], we decided to investigate the possible structural role of the N-terminus and the C-terminus of PufX. To this aim, nine strains of Rb. sphaeroides...
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Tài liệu Báo cáo khoa học: Role of the cag-pathogenicity island encoded type IV secretion system in Helicobacter pylori pathogenesis pptx
... control the amount of intracellu-lar CagAPY. Cortactin, ezrin and vinculin are all Srcsubstrates, and Src inactivation causes dephosphoryla-tion of these proteins and is crucial for triggering ... actin-binding proteins [6]. The phosphatasesinvolved in this scenario, however, remain unknown and do not require Shp2. Instead, CagAPYcan inhibitSrc activity both by direct interaction of ... distribution,making them unsuitable for the investigation of b-cate-nin signalling [29]. In support of this aspect, usingMadin–Darby canine kidney cells that expressE-cadherin and b-catenin without...
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Tài liệu Báo cáo khoa học: A novel c-N-methylaminobutyrate demethylating oxidase involved in catabolism of the tobacco alkaloid nicotine by Arthrobacter nicotinovorans pAO1 ppt
... C-terminal domain of MABO to otherproteins of the sarcosine dehydrogen ase and oxidase familymay indicate that this is the site of attachment of tetra-hydrofolate to the enzyme. c-Aminobutyrate ... generated during the catabolism of nicotine. The identification of this enzyme reveals, for the first time, the metabolic fate of the pyrrolidine ring of nicotine during the pAO1-dependent nicotine catabolism ... covalently attachedflavin, synthesized only in bacteria grown in the presence of nicotine The DNA carrying the sarcosine dehydrogenase-likeORF63, corresponding to a protein of 813 amino acidswith a...
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Tài liệu Báo cáo khoa học: Local stability identification and the role of a key aromatic amino acid residue in staphylococcal nuclease refolding pdf
... chain intoN-terminal and C-terminal centers during refolding[21]. Since then, many scientists have been interested in demonstrating this concept by using N-terminal and C-terminal fragments of ... located in the C-terminal loop of SNase playsan important role in protein stability and conforma-tional integrity. During protein unfolding ⁄ refolding, the addition of 2.5 protons (both E75 and ... protein that contains onedomain and no disulfide bonds. Its stability in the native state may bemaintained mainly by key amino acids. In this study, two point-mutatedproteins each with a single...
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Báo cáo khoa học: Role of the C-terminal extension in a bacterial tyrosinase Michael Fairhead and Linda Thony-Meyer doc
... motifArg40Cys84Tyr349Tyr347Lys370Ala36Ala36Ala36Val357Phe518BLaccaseTyrosinaseβ-sheet protein Fig. 1. Overview of the tyrosinase gene and surrounding genes in the genome of V. spinosum. (A) Showing the tyrosinasegene and those in its immediate vicinity in the ... meaning that the purification of holo protein in this way was impracticable. C-terminal processing by trypsinAs noted above, the C-terminal extension found in the latent form of mushroom tyrosinase ... binding motifs common to most tyrosinasesequences [3] that contain five of the six copper-bind-ing histidine ligands. The sixth histidine ligand found in tyrosinases typically occurs before the...
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Báo cáo khoa học: Role of DptE and DptF in the lipidation reaction of daptomycin ppt
... between the hydroxyl group of Thr4 and the C-terminal Kyn13, resulting in a ten-membered ring [8]. More-over, several ORFs localized within the gene clusterare associated with the biosynthesis of ... of DptE, weexpressed dptF using the pQTev vector in E. coli and purified the resulting ACP as an N-terminal His7 fusion protein (Fig. 3) with a yield of 9.5 mgÆL)1 of culture. The identity of ... is GLDSV,indicating that this putative ACP domain is one of the few ACPs in which valine replaces isoleucine (I) orleucine (L) in the conserved sequence. To determinewhether DptF is the putative...
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Báo cáo khoa học: Role of different moieties from the lipooligosaccharide molecule in biological activities of the Moraxella catarrhalis outer membrane pot
... that the OSs from the wild-type strain consisted of terminal-, 2-, 4-, and 3,4,6-linked glucosyl residues, terminal- and 4-linkedgalactosyl residues, and a terminal-linked N-acetylglu-cosaminosyl ... mutant contained a truncated core OS and consisted of a linker (Glc-Kdo2)-lipid A structure. The phenotype of this mutant was examined to investigate the roles of different moieties of the LOS ... MALDI-TOF-MS of de-O-acylated LOSfrom the mutant and glycosyl composition, linkage, and NMR analysis of its OS indicated that the LOS contained a truncated core OS and consisted of a Glc-Kdo2(linker)-lipid...
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