Báo cáo Y học: Investigations into the mechanisms used by the C-terminal anchors of Escherichia coli penicillin-binding proteins 4, 5, 6 and 6b for membrane interaction ppt
... Investigations into the mechanisms used by the C-terminal anchors
of
Escherichia coli
penicillin-binding proteins 4, 5, 6 and 6b
for membrane interaction
Frederick Harris
1
, Klaus Brandenburg
2
, ... have used theoretical analysis to
investigate the potential of the PBP4, PBP5, PBP6 and
PBP6b C-terminal regions for membrane interac...
... the sequences of 1CEV and 1RLA and pasted into the
structural alignment. The alignment was then corrected by
hand. Since the sequences of the two arginases and
agmatinase greately differ in the ... arginase (yellow) and the modelled structure of E. coli
agmatinase (blue). Note the shorter extension, in the case of E. coli
agmatinase, of the loop i...
... deeply into the membranes hydrophobic core.
To investigate further the mechanism of bacterial
membrane interaction used by AP1, thermodynamic
analysis of compression isotherms for lipid monolayer
mimetics ... hypo-
thesis of Tytler et al. [48], it may be that insertion of
the inverted wedge shape formed by the AP1 a-helix
into membranes of E. coli leads to...
... d b y
loose closure of the dura and skin layers presum a b l y
allows for expansion of the edematous brain into a
durotomy “bag” under the loosely closed scalp
without restriction by the ... meninges. The method
using temporal fascia is similar to the one introduced
by Yu et al.
32
They separated the temporal deep fascia
from the temporal muscle to th...
... Frequency of the MTHFR genotypes and the result of the Chi square testing in the different
studied groups. Showing the frequency and the results of the cross tabulation of the T allele and the
different ... 5-methyltetrahydrofolate as a carbon donor [6] . This donor is synthesized by the
methylenetetrahydrofolate reductase (MTHFR) gene from 5,1 0-methyl...
... infection, groups of tachycoites
multiply rapidly within intracellular cysts. The im-
mune response induces the formation of bradycoites
tightly packed in larger cysts containing hundreds of
organisms. ... than a century, the term
zoonosis indicated any disorder due to infectious
agents visible by microscope. Ironically, the first re-
ports of cytomegaly were attributed...
... material [ 46] . The
position of the amide I band, the major protein absorption
band, depends on the conformation of the polypeptide
chain [47]. The presence of this amide I absorption band at
165 6 cm
)1
suggests ... reverse-phase
HPLC of their phenylisothiocarbamate derivatives [ 26] , as
reported previously [20]. The serine, threonine and tyrosine
contents of th...
... decades of life and severely impair visual
acuity in adulthood. Their therapy is restricted to keratopl-
asty and phototherapeutic keratectomy by Excimer laser.
Unfortunately, the benefits of these therapies ... configuration and to form amyloid. The
CONH
2
-terminus of the peptides analyzed has an inhibitory
Fig. 6. Secondary structure determination of the peptides by...
... this yeast system and/ or the ability of
the enzymes further down the metabolic pathway to use the
products of the FAE1 KCS condensation activity. Indeed,
in the S. cerevisiae strain used in these ... However, the results are reflective of the entire
yeast metabolic pathways from the synthesis of 3-ketoacyl
CoAs by a condensing enzyme to the incorporation of...
... study is that the translation of
agonist binding to the ATDs of the family C GPCR
homodimer into G-protein coupling of the 7TM)7TM
moiety is mediated by another mechanism than that
proposed by ... activity in the receptor [59], and the
splice variants of mGluR1 and mGluR5 with long carboxy
termini are constitutively active [60 ,61 ]. All these pheno-
mena origina...