... in the 1970s that catalyzed the modern era wave of clinical and scientifi c research into the causes, mechanisms, and treatment of Alzheimer ’ s disease and related dementias. The fi rst of these ... $50,000 per year, and over $300 billion per annum globally (Dartigues, 2009 ). We therefore need hardly emphasize the current and growing economic impact of AD, the “ coming plague of the 21st century, ... estab-lished with funding from the National Institute on Aging. These Centers, which now number 30 across the United States, are the focal point for much of the clinical and scientifi c research conducted...