Báo cáo khoa học: Modeled ligand-protein complexes elucidate the origin of substrate specificity and provide insight into catalytic mechanisms of phenylalanine hydroxylase and tyrosine hydroxylase pptx

Báo cáo khoa học: Modeled ligand-protein complexes elucidate the origin of substrate specificity and provide insight into catalytic mechanisms of phenylalanine hydroxylase and tyrosine hydroxylase pptx

Báo cáo khoa học: Modeled ligand-protein complexes elucidate the origin of substrate specificity and provide insight into catalytic mechanisms of phenylalanine hydroxylase and tyrosine hydroxylase pptx

... PAH and TH (Eur. J. Biochem. 270) 1075 Modeled ligand-protein complexes elucidate the origin of substrate specificity and provide insight into catalytic mechanisms of phenylalanine hydroxylase and ... binding to the catalytic domains of PAH and TH Docking of the native cosubstrate BH 4 into the crystal structure of the PAH catalytic...
Ngày tải lên : 31/03/2014, 07:20
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Báo cáo khoa học: by nucleotide affinity cleavage: a distinct nucleotide specificity of the C-terminal ATP-binding site potx

Báo cáo khoa học: by nucleotide affinity cleavage: a distinct nucleotide specificity of the C-terminal ATP-binding site potx

... conclusion, the present studies provide the first systematic and detailed characterization of the nucleotide binding specificity of the N- and C-terminal nucleotide binding sites of the 90-kDa molecular chaperone, ... an intact adenine ring; the stick model is the structure of the kinked ADP in the Hsp90 crystal, the phosphates pointing out of the domain;...
Ngày tải lên : 08/03/2014, 02:21
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Báo cáo khoa học: "Learning How to Conjugate the Romanian Verb. Rules for Regular and Partially Irregular Verbs" docx

Báo cáo khoa học: "Learning How to Conjugate the Romanian Verb. Rules for Regular and Partially Irregular Verbs" docx

... looking at the inflection of the verbs and number of allomorphs of the stem. Romalo (1968, p. 5-203) produced a list of 38 verb types, which she eventually reduced to 10. For the purpose of machine ... alternations occuring in the stem of irregular and partially irregular verbs. The system of rules presented below took into account both the end- ings pattern...
Ngày tải lên : 17/03/2014, 22:20
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Báo cáo khoa học: Ixocarpalactone A isolated from the Mexican tomatillo shows potent antiproliferative and apoptotic activity in colon cancer cells pot

Báo cáo khoa học: Ixocarpalactone A isolated from the Mexican tomatillo shows potent antiproliferative and apoptotic activity in colon cancer cells pot

... bioas- says specific to the extract. Pure compounds are then isolated from active fractions and the structure of the compound is determined. The activity of the chemo- preventive agent is then confirmed ... focus on IxoA because of its abundance in the leaves and stems of the plant and its presence in the fruits. To examine the mechanism that might account for t...
Ngày tải lên : 23/03/2014, 10:20
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Tài liệu Báo cáo khoa học: S100–annexin complexes – biology of conditional association doc

Tài liệu Báo cáo khoa học: S100–annexin complexes – biology of conditional association doc

... S100–annexin complexes have a role in the differentiation of gonad cells and neurological disor- ders, such as depression. These complexes regulate the organization of membranes and vesicles, and thereby ... Ca 2+ via EF-hand motifs and undergo large conformational changes. These changes induce the exposure of a hydrophobic patch at the surface of these molecules...
Ngày tải lên : 18/02/2014, 14:20
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Tài liệu Báo cáo khoa học: S100–annexin complexes – structural insights pptx

Tài liệu Báo cáo khoa học: S100–annexin complexes – structural insights pptx

... that the acetyl group aids in the stabilization of the helix dipole of the annexin N-terminus, and therefore the required helical confor- mation of the peptide. The rmsd for the backbones for the ... each of the hydrophobic residues are labelled. For example, the side-chain of L7 of annexin A1 is within 6 A ˚ of the side-chains of L45, A47, F48 within...
Ngày tải lên : 18/02/2014, 14:20
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Báo cáo khoa học: A single mismatch in the DNA induces enhanced aggregation of MutS Hydrodynamic analyses of the protein-DNA complexes pot

Báo cáo khoa học: A single mismatch in the DNA induces enhanced aggregation of MutS Hydrodynamic analyses of the protein-DNA complexes pot

... either ‘Regularization’ or DynaLS analysis of the entire set (¼ 10) of curves. The goodness of the fit by DynaLS software was evaluated by visual inspection of residual distribution (random and ... obviates the need of looping of intervening DNA. The in vivo data supporting the MutS–MutL foci formation suggests the possibility of extensive recruitment of protein...
Ngày tải lên : 07/03/2014, 12:20
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Báo cáo khoa học: Data-driven docking for the study of biomolecular complexes pptx

Báo cáo khoa học: Data-driven docking for the study of biomolecular complexes pptx

... partly depends on the kind of data used (e.g. the level of detail and the amount of inherent ambiguity) and the sampling method. ‘Geometric’ methods might limit the number of orientations selected ... microscopy and tomography can also provide valuable information about the ‘shape’ and organiza- tion of biomolecular complexes. As these are rather different kin...
Ngày tải lên : 30/03/2014, 15:20
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Tài liệu Báo cáo khoa học: An alternative isomerohydrolase in the retinal Muller cells of a cone-dominant species doc

Tài liệu Báo cáo khoa học: An alternative isomerohydrolase in the retinal Muller cells of a cone-dominant species doc

... all-trans retinol (atROL) as the substrate for the conversion of 11cROL [24–27]; the substrate of RPE65 in the RPE is atRE [12]. To verify the substrate specificity of zebra- fish RPE65c, total ... the area of the 11cROL and 13cROL peaks and expressed as the mean ± SD of three independent measurements. Retinal cell dissociation The zebrafish eyes were enuc...
Ngày tải lên : 14/02/2014, 14:20
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Tài liệu Báo cáo khoa học: Stefin A displaces the occluding loop of cathepsin B only by as much as required to bind to the active site cleft doc

Tài liệu Báo cáo khoa học: Stefin A displaces the occluding loop of cathepsin B only by as much as required to bind to the active site cleft doc

... stefin A and the different enzymes is the average distance between the centre of mass of CA atoms of the stefin molecule and the centre of mass of the CA atoms of the reactive site cysteine and histidine ... its original position. A comparison of the structure of the unli- ganded cathepsin B with the structure of the proenzyme, its complexes with...
Ngày tải lên : 18/02/2014, 04:20
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