... against S6 and the GST-tag. (C) Immunoblot analysis of thephosphorylation status of p70S6K and S6 inPaskin+ ⁄ + and Paskin) ⁄ )MEFs. (D) Immu-noblot analysis of the phosphorylation status of p70S6K ... addressesDivision of Digestive and Liver Diseases,Department of Medicine, ColumbiaUniversity, New York, NY, USAàInstitute of Cell Biology, ETH Zu¨rich,Switzerland§Biogen-Dompe´, Zug, Switzerland(Received ... Ser ⁄ Thr kinase (PSK)1 and PSK2, the bud-ding yeast homologues of PASKIN, phosphorylatethree translation factors and two enzymes involved inthe regulation of glycogen and trehalose synthesis,thereby...