... adenosine dialdehyde; AMI, arginine methylation inhibitor; IL, interleukin; GST, glutathione S-transferase; GST–GAR, GST fused to theglycine-rich and arginine-rich region of fibrillarin; IFN-c, interferon-c; ... the direct inhibition of PRMTs. As a SAM analog,sinefungin can compete for SAM binding and inhibitthe activity of all SAM-dependent methyltransferases,including PRMTs [8]. Removal of the methyl ... activity and cellular protein arginine methylation, including methyl-ation of the guanine nucleotide exchange factor Vav1[5]. Incubation with MDL 28,842 diminished methyla-tion of the guanine exchange...