... meanthat the phosphonodipeptide is actually transported into the cells. Interaction with PEPT1 and PEPT2, the fact thatbacterial permeases take up alafosfalin [11–14] and the known oral availability ... 272, 56–58.2.Arisawa,M.,Ohshima,J.,Ohsawa,E.&Maruyama ,H. B.(1982) In vitro potentiation of cephalosporins by alafosfalinagainst urinary tract bacteria. Antimicrob. Agents Chemother. 21,706–710.3. ... by alafosfalin; in the presence of alafosfalin the Ktvalue of Gly-Sar uptakein Caco-2 cells was 1160 lMcompared to 580 lMin the absence of the inhibiting phosphonodipeptide. The samealafosfalin...