Báo cáo khoa học: Sugar and alcohol molecules provide a therapeutic strategy for the serpinopathies that cause dementia and cirrhosis pot

... 2006 The Authors Journal compilation ª 2006 FEBS Sugar and alcohol molecules provide a therapeutic strategy for the serpinopathies that cause dementia and cirrhosis Lynda K. Sharp1,*, Meera Mallya1,*, ... Miranda E, Ro¨misch K & Lomas DA (2004) Mutantsof neuroserpin that cause dementia accumulate as poly- A therapeutic strategy for the serpinopathies L. K. Sharp et al.2550 FEBS Journal ... wild-typeneuroserpin and the Ser49Pro mutant that causes dementia. They alsoattenuate the polymerization of the Z variant of a 1-antitrypsin. The effecton polymerization was apparent even when these agents had...

Tài liệu Báo cáo khoa học: What makes biochemical networks tick? A graphical tool for the identiﬁcation of oscillophores ppt

... of the type o f Graph 1 (these paths may containparallel and antiparallel arrows). The sign of that elementtherefore depends on the both the sign and the magnitudesof these influen ce paths ... s ubstance on the right i s a substrate o f the reaction.Then the a rrow points b ackward, i.e. a way from t hesubstance and there is a right-hand factor – a equal to )1.Influences of the type ... its degradation ( a js a js) and a second influencethrough its autocatalytic feedback ( +a jsbjs) through the same reaction, vs. The latter influences cancel each other,again as all stoichiometries...

Tài liệu Báo cáo khoa học: Diol dehydratase-reactivating factor is a reactivase – evidence for multiple turnovers and subunit swapping with diol dehydratase pdf

... the enzymeÆreactivase complex was formed in smallamounts from apoenzyme and the reactivase and not atall from the enzymeÆCN-Cbl complex and the reactivase(data not shown).Afﬁnity of the reactivase for ... contrast, a peak of the freereactivase decreased and a new peak appeared in the presence of ADP. The latter peak was eluted with a Table 2. Nucleotide and divalent cation speciﬁcities of the reactivase ... nondenaturing PAGE, the bands of the enzyme and the reactivase were markedly reducedin density, and two bands of the enzymeÆreactivasecomplexes (upper and lower) appeared above them(Fig. 5A, lane...

Tài liệu Báo cáo khoa học: "Exploiting Readymades in Linguistic Creativity: A System Demonstration of the Jigsaw Bard" docx

... withsalient properties Adj A 1 and Adj A 2 respec-tively, such that Adj A 1 and Adj A 2 are mutu-ally reinforcing. The combination is indexedon Adj A 1+Adj A2 . Example: “as dark and sophisticated ... instances of the patterns“as ADJ and * as” and “as * and ADJ as” fromGoogle, noting the combinations that are found and their frequencies. These frequencies provide linkweights for the Hofstadter-style ... orrestaurant names, or the names of racehorses, and so on, and on. The 1996 movie The Usual Suspectstakes its name from a memorable scene in 1942’sCasablanca, as does the Woody Allen play and movie...

Tài liệu Báo cáo khoa học: "Acquiring Lexical Generalizations from Corpora: A Case Study for Diathesis Alternations" pdf

... estimates and typicality values for the dative and benefactive alternation to produce a novel form (Briscoe and Copestake, 1996). 6 Typicality Estimating the productivity of an alternation for ... class for a given alternation. The underlying assumption is that a verb is typical for an alternation if it is equally frequent for both frames which are characteristic for the alternation. ... alternation and cause, spoil, afford and prescribe for the benefactive), and 12 can appear in either frame but do not alter- nate (e.g., appoint, fix, proclaim). For 18 verbs two frames...

Báo cáo khoa học: Identiﬁcation of NF1 as a silencer protein of the human adenine nucleotide translocase-2 gene pptx

... mammalian cells. Both catalyse the exchange of mitochondrial ATP for cytosolic ADP, therebyplaying key roles in maintaining the cytosolic phosphory-lation potential, adenylate charge, and the ... wereseparated on 4% nondenaturing polyacrylamide gel. The gels were dried and autoradiographed. Competitor DNAsused in EMSA analysis were: NF1 wt, 5¢-TTTTGGATTGAAGCCAATATGATA-3¢;NF1mut,5¢-TTTTGGATTGAATAAAATATGATA-3¢;Site-2wt,5¢-GCGTCTCACCCTAGTCCTGGTCCTGCTCCAAGGGTTTTTGTCC-3¢;Site-2mut,5¢-GCGTCTCACCCTAGTAATGGTAATGCTCCAAGGGTTTTTGTCC-3¢;Site-3wt,5¢-GGGTTCTTTTGGCATCCCTGTAGC-3¢;Site-3mut,5¢-GGGTTCTTTTTAAATCCCTGTAGC-3¢.Chromatin ... Ampliﬁcation of immunoprecipitated DNA frag-ments (2 lL) was performed using the primer set: )525(5¢-TGACCTTGTCTCGTTGCCTCACCC-3¢ )and) 378(5¢-GCTACAGGGATGCCAAAAGAACCC-3¢)fortheSite-3, and primer...

Báo cáo khoa học: "Grammar Approximation by Representative Sublanguage: A New Model for Language Learning" potx

... grammar lattice. All grammars generate , and only generates ( is a common lexicon for all the grammars)3 A Grammar Lattice as a Search Space for Grammar InductionIn this section we present a ... molecules .3 The language of a grammaris the set of allsyntagmas generated from the start symbol , i.e.,. The set of all syntagmas generated by a grammaris. Given a LWFG we call a set a sublanguage ... grammarfrom a small number of natural languagestrings annotated with their semantics, alongwith basic assumptions about natural lan-guage syntax. We show that the search space for grammar induction...

Báo cáo khoa học: "From Information Structure to Intonation: A Phonological Interface for Concept-to-Speech" pot

... handling uses the FUF formalism and the same ratification machinery as the grammar. formation like (potential) accent and syllable boundary positions. Input to the synthesizer is a SAMPA ... provided as well. Compared to text-to-speech the task is at the same time easier and more difficult. In- formation from pragmatic, semantic and syn- tactic layers are readily available. This ... Speech S~'nthesis / Figure 1: Architecture This architecture forms an ideal platform for the implementation of the phonological interface. Necessary adaptions are limited to the data used:...

Báo cáo khoa học: Fatty acid omega-oxidation as a rescue pathway for fatty acid oxidation disorders in humans pot

... includingstraight- and branched-chain FAs, as well as mono- and polyunsaturated FAs. There is one exception,however, and that is if the carbon-3 has a methyl- orany other functional group attached. ... blindness with anosmia, cerebellarataxia and a range of other more variable abnormali-ties. The only therapy available to date is a life-longdiet low in phytanic acid, which may stop further pro-gression ... myristic acid (tetradecanoicacid), palmitic acid (hexadecanoic acid) and the unsat-urated FAs oleic acid [(Z)-octadec-9-enoic acid] and arachidonic acid (all-cis-5,8,11,14-eicosatetraenoic acid)[34]....

Báo cáo khoa học: NMR solution structure of Cn12, a novel peptide from the Mexican scorpion Centruroides noxius with a typical b-toxin sequence but with a-like physiological activity doc

... effect (for those that modify the gating mechanism) and Cn11 (a blocking toxin). Weexpect that, when more data become available, the conceptson the interaction of Na-ScTxs and Na+channels ... whereas smallcontaminants (5%) were eliminated on the ascending and descending sections of the chromatogram. (B) Direct Edman degrada-tion of native peptide and reduced and alkylated samples provided ... NMR analysis of pure Cn12. It waspossible to analyze the NMR data because of well-dispersedsignals obtained at 11.75 T. Figure 4A shows the NOEdiagram of sequential and medium range data, the...

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