Báo cáo khoa học: The role of Ureaplasma nucleoside monophosphate kinases in the synthesis of nucleoside triphosphates potx

Báo cáo khoa học: Relationship between functional activity and protein stability in the presence of all classes of stabilizing osmolytes ppt

... leading to the preferential hydration of the protein domain is the driving force of protein stabiliza-tion or folding [3,4]. Furthermore, the effect of osmolytes on the functional activity of ... DGD° values in the presence of these osmolytes are given in Table 1. How-ever, DGD° values of RNase-A in the presence of alanine, serine, lysine, b-alanine, taurine and dimethyl-glycine have ... [36,references therein]. The binding model claims that anincrease in the osmolyte-induced stability arises from the preferential hydration (or exclusion of the osmo-lyte) leading to a shift in the denaturation...

Báo cáo khoa học: "COMMON TOPICS AND COHERENT SITUATIONS: INTERPRETING ELLIPSIS IN THE CONTEXT OF DISCOURSE INFERENCE" ppt

... with in the treatment of VP-eUipsis, perhaps at the cost of some degree of the- oretical inelegance. However, this aspect was crucial for handling the gapping data, since the infelicity of gapping ... that reinforces one of the meanings. For instance, gapping is felicitous in passage (3), where context supports the symmetric reading, but is infelicitous in passage (4) under the intended ... referential forms as to whether they leave behind an empty constituent in the syntax and whether they are anaphoric in the semantics. Empty. constituents in the syntax are not in themselves refer-...

Báo cáo khoa học: An E3 ubiquitin ligase, Synoviolin, is involved in the degradation of immature nicastrin, and regulates the production of amyloid b-protein doc

... deletion of Synoviolin causes a change in the intracellular trafﬁcking of NCT.Effect of Synoviolin on the production of AbNCT is one of the essential cofactors of the c-secretasecomplex. We therefore ... SupportingInformation). We also determined the levels of c-secre-tase-unrelated ER protein (calnexin) and cytoskeletonprotein (tubulin) in these cells as the internal controlproteins. The calnexin ... generation.ResultsAccumulation of immature NCT in synoviolin-nullcellsTo investigate whether Synoviolin is involved in the degradation of PS cofactors, we ﬁrst compared the levels of PS cofactors by immunoblotting betweensynoviolin-null...

Báo cáo khoa học: A novel factor XI missense mutation (Val371Ile) in the activation loop is responsible for a case of mild type II factor XI deﬁciency doc

... explained by the proximity of the mutation to the cleavage site, probably resulting in asmall interference with the binding of the activator to the FXI zymogen.There are some examples of inherited ... activation loop at the N-terminus of the catalyticdomain, are notable. In the zymogen FXI, Ile371 is exposed to the solvent, while in the activated FXI it is inserted into the protein. The picture ... (1993) The linkage between binding of the C-terminal domain of hirudin and amidase activity in human alpha-throm-bin. Biochem J 289, 475–480.45 Baglia FA & Walsh PN (1996) A binding site...

Báo cáo khoa học: "A Feedback-Augmented Method for Detecting Errors in the Writing of Learners of English" docx

... errors since they are based on the articlesand the distinction between singular and plural.Finally, the tagged instances are stored in a filewith their surrounding words. Each line of it con-sists ... 1(a)?modified by one of the words in Table 1(b)?modified by one of the words in Table 1(c)?Figure 1: Framework of the tagging rulesTable 1: Words used in the tagging rules(a) (b) (c) the indefinite article ... detected in thisstep, the rest of the steps are not applied. In the second step, errors are detected by the rules described in Table 3. The symbol “” in Ta-ble 3 denotes that the combination of the...

Tài liệu Báo cáo khoa học: "A Multimodal Interface for Access to Content in the Home" pdf

... understanding of system capa-bilities. Of the remaining 66% of inputs (2166) which were within the functionality of the system, 68% were in grammar. On the within functionality portion of the data, ... sets of scenarios and then freely interacting with each system. For counterbalancing purposes, half of the subjects used the tablet and then the re-mote control and the other half used the ... select items. The pen can be used both for selecting items (pointing at them) and for handwritten input. The graphical user interface has three main screens. The main screen is the search screen...

Báo cáo khoa học: Insights into substrate and product trafﬁc in the Drosophila melanogaster acetylcholinesterase active site gorge by enlarging a back channel ppt

... hinder the entrance of acetylcholine to the CAS in the wild-type enzyme, it appears that, in the two mutants(Trp83Ala ⁄ Glu), inhibitors that bind to the PAS didnot prevent the entrance of ... mutants: the strong decrease of inhibition of propidium [21] and the increase of remaining activity upon peripheral site saturation byfasciculin [24].Finally, minor deviations of pS curves upon binding of ... used the speciﬁc equation in Scheme 1. The effect of two ligands on the activity of the wild-type DmAChE was evaluated by the equation in Scheme 1 enlarged by the intermediates, repre-senting the...

Báo cáo khóa học: A single mutation that causes phosphatidylglycerol deﬁciency impairs synthesis of photosystem II cores in Chlamydomonas reinhardtii pdf

... displayconcerted rates of synthesis. In the absence of D1, the rate of synthesis of apoCP47 is strongly reduced, while the rates of synthesis of both D1 and apoCP47 drops when D1 cannotassemble within PSII ... process of the cotranslationalinsertion of the D1 protein into the thylakoid membrane,then one could imagine that the absence of PG leads to adrop in translational elongation of the D1 protein. Indeedanionic ... degradation or to their lower rate of synthesis. When we studied the rates of synthesis of the individual PSII subunits by 5 min pulse-labelling experi-ments, we observed that synthesis of D1 and apoCP47...

Báo cáo khoa học: Evidence for two different electron transfer pathways in the same enzyme, nitrate reductase A from Escherichia coli potx

... fumarate reduction; the use of the quinol-binding site inhibitor HOQNO shows that the inhibitor blocks binding of MQH2at the QPsite [27].Study of the reduction and oxidation of the cytochromehas ... determine binding sites of quinols,inhibition by HOQNO (a structural analogue of menaqui-none), did not allow them to see the binding site of ubiquinol because HOQNO is not an inhibitor for the ubiqinones. ... advantage of notdiluting the reducing solutions, thus allowing the addition of smaller quantities for the same reducing effect. In any event, the results obtained are equivalent whatever the mode of reduction...

Báo cáo khoa học: H2O2, but not menadione, provokes a decrease in the ATP and an increase in the inosine levels in Saccharomyces cerevisiae An experimental and theoretical approach pot

... accompanied by an increase in the rate of synthesis of Ino, without any need to modify the kineticparameters or activities of the enzymes involved in the pathway from ATP to Ino.Being aware of the simpliﬁcations ... concentration in a metabolic path-way as a function of the kinetic constants of the enzymesinvolved in that pathway [3]. Application of this methodpointed to the inhibition of the rate of synthesis of ... that (a) the main if not unique source of inosine is the intracellularpool of adenine nucleotides, (b) the decrease in ATP and the increase in inosine, promoted by H2O2, cannot be explainedsolely...

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